DIO3 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 432 Sequence: atgctccgct ccctgctgct tcactccttg aggctctgcg cccagaccgc ctcgtgcctc gtgctcttcc cgcgcttcct cggcacggcc ttcatgctct ggcttctcga tttcttgtgt atccgcaagc atttcctggg ccgccgccgc cgggggcagc ccgagcccga agtggagctc aacagtgaag gcgaggaggt gcctcccgat gacccgccca tctgcgtgtc cgacgacaac cgcctgtgca ccctggcgtc gctcaaggcg gtgtggcatg gccagaagtt ggatttcttc aagcaggcgc acgagggcgg tccggcgccc aactccgagg tggttctgcc cgacggcttc cagagccagc acatcctcga ctacgcgcaa gggaaccgcc cgctggttct caatttcggc agctgcacct Protein function: Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development. [The UniProt Consortium]