DIAPH3 (Vector pENTR223.1, Accession No. BC048963)

Length: 2550 Sequence: atgagtgagg agaggagcct ttccttattg gccaaagccg tggatcccag acaccccaat atgatgacag atgtggttaa acttctctct gcggtatgca ttgtagggga agaaagcatc cttgaagaag ttttagaagc tttaacttca gctggtgaag aaaaaaaaat tgacagattt ttttgtattg tggaaggcct ccggcacaat tcagttcaac tgcaagtagc ttgtatgcag ctcatcaatg ccctggttac atctcctgat gatttggatt tcaggcttca catcagaaat gaatttatgc gttgtggatt gaaagagata ttgccaaatt taaaatgcat taagaatgat ggcctggata tccaacttaa agtctttgat gagcataaag aagaagattt gtttgagtta tcccatcgcc ttgaagatat tagagctgaa cttgatgaag catatgatgt ttacaacatg gtgtggagca cagttaaaga aactagagca gagggatatt ttatttctat tcttcagcat cttttgctga ttcgaaatga ttattttata aggcaacaat acttcaaatt aattgatgag tgtgtatccc agattgtatt gcatagagat ggaatggatc cagacttcac atatcgaaaa agactagatt tagatttaac ccagtttgta gacatttgca tagatcaagc aaaactagaa gagtttgaag agaaagcatc agaactttac aagaaatttg aaaaagagtt taccgaccac caagaaactc aggctgaatt gcagaaaaaa gaggcaaaga ttaatgagct tcaagcagag ctacaagctt ttaagtctca gtttggtgcc ttgccagctg attgtaatat tcctttgcct ccctctaaag aaggtggaac tggccactca gcacttcctc ctccgcctcc actgccttct ggtggagggg tgccgcctcc acctcctccc ccaccacctc ctccacttcc aggaatgcgg atgccattca gtggtcctgt gcctccacca cctcccctgg gattccttgg aggacaaaat tctcctcctc taccaatcct gccatttggg ttgaaaccaa agaaagaatt taaacctgaa atcagcatga gaagattgaa ttggttaaag atcagacctc atgaaatgac tgaaaactgt ttctggataa aagtaaatga aaataagtat gaaaacgtgg atttgctttg taaacttgag aatacatttt gttgccaaca aaaagagaga agagaagagg aagatattga agagaagaaa tcgattaaga aaaaaattaa agaacttaag tttttagatt ctaaaattgc ccagaacctt tcaatcttcc tgagctcttt tcgggtgcca tatgaggaaa tcagaatgat gatattggaa gtagatgaaa cacggttggc agagtctatg attcagaact taataaagca tcttcctgat caagagcaat taaattcatt gtctcagttc aagagtgaat atagcaactt atgtgaacct gagcagtttg tggttgtgat gagcaatgtg aagagactac ggccacggct cagtgctatt ctctttaagc ttcagtttga agagcaggtg aacaacatca aacctgacat catggctgtc agtactgcct gcgaagagat aaagaagagc aaaagcttta gcaagttgct ggaacttgta ttgctaatgg gaaactacat gaatgctggc tcccggaatg ctcaaacctt cggatttaac cttagctctc tctgtaaact aaaggacaca aaatcagcag atcagaaaac aacgctactt catttcctgg tagaaatatg tgaagagaag taccctgata tactgaattt tgtggatgat ttggaacctt tagacaaagc tagtaaagtc tctgtagaaa cgctggaaaa gaatttgagg cagatgggaa ggcagcttca acagcttgag aaggaattgg aaacctttcc ccctcctgag gacttgcatg acaagtttgt gacaaagatg tccagatttg ttatcagtgc aaaagaacaa tatgagacac tttcgaagtt acacgaaaac atggaaaagt tataccagag tataatagga tactatgcca ttgatgtgaa gaaggtgtct gtggaagact ttcttactga cctgaataac ttcagaacca cattcatgca agcaataaag gagaatatca aaaaaagaga agcagaggaa aaagaaaaac gtgtcagaat agctaaagaa ttagcagagc gagaaagact cgaacgccaa caaaagaaaa agcgtttatt agaaatgaag actgagggtg atgagacagg agtgatggat aatctgctgg aggccttgca gtccggggct gccttccgcg acagaagaaa aaggacaccg atgccaaaag atgttcggca gagtctcagt ccaatgtctc agaggcctgt tctgaaagtt tgtaaccatg gtaataaacc Protein function: Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor. Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity. [The UniProt Consortium]