DHDDS (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1002 Sequence: atgtcatgga tcaaggaagg agagctgtca ctttgggagc ggttctgtgc caacatcata aaggcaggcc caatgccgaa acacattgca ttcataatgg acgggaaccg tcgctatgcc aagaagtgcc aggtggagcg gcaggaaggc cactcacagg gcttcaacaa gctagctgag actctgcggt ggtgtttgaa cctgggcatc ctagaggtga cagtctacgc attcagcatt gagaacttca aacgctccaa gagtgaggta gacgggctta tggatctggc ccggcagaag ttcagccgct tgatggaaga aaaggagaaa ctgcagaagc atggggtgtg tatccgggtc ctgggcgatc tgcacttgtt gcccttggat ctccaggagc tgattgcaca agctgtacag gccacgaaga actacaacaa gtgtttcctg aatgtctgtt ttgcatacac atcccgtcat gagatcagca atgctgtgag agagatggcc tggggggtgg agcaaggcct gttggatccc agtgatatct ctgagtctct gcttgataag tgcctctata ccaaccgctc tcctcatcct gacatcttga tacggacttc tggagaagtg cggctgagtg acttcttgct atggcagacc tctcactcct gcctggtgtt ccaacccgtt ctgtggccag agtatacatt ttggaacctc ttcgaggcca tcctgcagtt ccagatgaac catagcatgc ttcagaaggc ccgagacatg tatgcagagg agcggaagag gcagcagctg gagagggacc aggctacagt gacagagcag ctgctgcgag aggggctcca agccagtggg gacgcccagc tccgaaggac acgcttgcac aaactctcgg ccagacggga agagcgagtc caaggcttcc tgcaggcctt ggaactcaag cgagctgact ggctggcccg tctgggcact gcatcagcct Protein function: With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PubMed:25066056, PubMed:28842490, PubMed:32817466). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length (PubMed:32817466). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol (PubMed:21572394). [The UniProt Consortium]