DHDDS (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 885 Sequence: atgtcatgga tcaaggaagg agagctgtca ctttgggagc ggttctgtgc caacatcata aaggcaggcc caatgccgaa acacattgca ttcataatgg acgggaaccg tcgctatgcc aagaagtgcc aggtggagcg gcaggaaggc cactcacagg gcttcaacaa gctagctgag actctgcggt ggtgtttgaa cctgggcatc ctagaggtga cagtctacgc attcagcatt gagaacttca aacgctccaa gagtgaggta gacgggctta tggatctggc ccggcagaag ttcagccgct tgatggaaga aaagtgtttc ctgaatgtct gttttgcata cacatcccgt catgagatca gcaatgctgt gagagagatg gcctgggggg tggagcaagg cctgttggat cccagtgata tctctgagtc tctgcttgat aagtgcctct ataccaaccg ctctcctcat cctgacatct tgatacggac ttctggagaa gtgcggctga gtgacttctt gctatggcag acctctcact cctgcctggt gttccaaccc gttctgtggc cagagtatac attttggaac ctcttcgagg ccatcctgca gttccagatg aaccatagcg tgcttcagaa ggcccgagac atgtatgcag aggagcggaa gaggcagcag ctggagaggg accaggctac agtgacagag cagctgctgc gagaggggct ccaagccagt ggggacgccc agctccgaag gacacgcttg cacaaactct cggccagacg ggaagagcga gtccaaggct tcctgcaggc cttggaactc aagcgagctg actggctggc ccgtctgggc actgcatcag Protein function: With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PubMed:25066056, PubMed:28842490, PubMed:32817466). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length (PubMed:32817466). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol (PubMed:21572394). [The UniProt Consortium]