DERL1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 756 Sequence: atgtcggaca tcggagactg gttcaggagc atcccggcga tcacgcgcta ttggttcgcc gccaccgtcg ccgtgccctt ggtcggcaaa ctcggcctca tcagcccggc ctacctcttc ctctggcccg aagccttcct ttatcgcttt cagatttgga ggccaatcac tgccaccttt tatttccctg tgggtccagg aactggattt ctttatttgg tcaatttata tttcttatat cagtattcta cgcgacttga aacaggagct tttgatggga ggccagcaga ctatttattc atgctcctct ttaactggat ttgcatcgtg attactggct tagcaatgga tatgcagttg ctgatgattc ctctgatcat gtcagtactt tatgtctggg cccagctgaa cagagacatg attgtatcat tttggtttgg aacacgattt aaggcctgct atttaccctg ggttatcctt ggattcaact atatcatcgg aggctcggta atcaatgagc ttattggaaa tctggttgga catctttatt ttttcctaat gttcagatac ccaatggact tgggaggaag aaattttcta tccacacctc agtttttgta ccgctggctg cccagtagga gaggaggagt atcaggattt ggtgtgcccc ctgctagcat gaggcgagct gctgatcaga atggcggagg cgggagacac aactggggcc agggctttcg acttggagac Protein function: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded protein (PubMed:15215856). Also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). By controlling the steady- state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). [The UniProt Consortium]