DENND1B (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 1281 Sequence: atggactgca ggaccaaggc aaatccagac agaacctttg acttggtgtt gaaagtgaaa tgtcatgcct ctgaaaatga agatcctgtg gtattgtgga aattcccaga ggactttgga gaccaggaaa tactacagag tgtgccaaag ttctgttttc cctttgacgt tgaaagggtg tctcagaatc aagttggaca gcactttacc tttgtactga cagacattga aagtaaacag agatttggat tctgcagact gacgtcagga ggcacaattt gtttatgcat ccttagttac cttccctggt ttgaagtgta ttacaagctt ctaaatactc ttgcagatta cttggctaag gaactggaaa atgatttgaa tgaaactctc agatcactgt ataaccaccc agtaccaaag gcaaatactc ctgtaaattt gagtgtgaac caagagatat ttattgcctg tgagcaagtt ctgaaagatc agcctgctct agtaccgcat tcctacttca ttgcccctga tgtaactgga ctcccaacaa tacccgagag tagaaatctt acagaatatt ttgttgccgt ggatgtgaac aacatgctgc agctgtatgc cagtatgctg catgaaaggc gcatcgtgat tatctcgagc aaattaagca ctttaactgc ctgtatccat ggatcagctg ctcttctata cccaatgtat tggcaacaca tatacatccc agtgcttcct ccacacctgc tggactactg ctgtgcccca atgccatacc tgattggaat acactccagc ctcatagaga gagtgaaaaa caaatcattg gaagatgttg ttatgttaaa tgttgataca aacacattag aatcaccatt tagtgacttg aacaacctac caagtgatgt ggtctcggcc ttgaaaaata aactgaagaa gcagtctaca gctacgggtg atggagtagc tagggccttt cttagagcac aggctgcttt gtttggatcc tacagagatg cactgagata caaacctggt gagcccatca ctttctgtga ggagagtttt gtaaagcacc gctcaagcgt gatgaaacag ttcctggaaa ctgccattaa cctccagctt tttaagcagt ttatcgatgg tcgactggca aaactaaatg caggaagggg tttctctgat gtatttgaag aagagatcac ttcaggtggc ttttgtggag gtaaagacaa gttacaatat gattatccat tttctcaata Protein function: Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells (PubMed:20154091, PubMed:20937701, PubMed:24520163, PubMed:26774822). Acts by promoting the exchange of GDP to GTP, converting inactive GDP- bound RAB35 into its active GTP-bound form (PubMed:20154091, PubMed:20937701). Plays a role in clathrin-mediated endocytosis (PubMed:20154091). Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity (PubMed:26774822). Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells (PubMed:26774822). [The UniProt Consortium]