DEF6 (Vector pENTR223.1, Accession No. BC017504)

Length: 1011 Sequence: atggccctgc gcaaggaact gctcaagtcc atctggtacg cctttaccgc gctggacgtg gagaagagtg gcaaagtctc caagtcccag ctcaaggtgc tgtcccacaa cctgtacacg gtcctgcaca tcccccatga ccccgtggcc ctggaggaac acttccgaga tgatgatgac ggccctgtgt ccagccaggg atacatgccc tacctcaaca agtacatcct ggacaaggtg gaggaggggg cttttgttaa agagcacttt gatgagctgt gctggacgct gacggccaag aagaactatc gggcagatag caacgggaac agtatgctct ccaatcagga tgccttccgc ctctggtgcc tcttcaactt cctgtctgag gacaagtacc ctctgatcat ggttcctgat gaggtggaat acctgctgaa aaaggtactc agcagcatga gcttggaggt gagcttgggt gagctggagg agcttctggc ccaggaggcc caggtggccc agaccaccgg ggggctcagc gtctggcagt tcctggagct cttcaattcg ggccgctgcc tgcggggcgt gggccgggac accctcagca tggccatcca cgaggtctac caggagctca tccaagatgt cctgaagcag ggctacctgt ggaagcgagg gcacctgaga aggaactggg ccgaacgctg gttccagctg cagcccagct gcctctgcta ctttgggagt gaagagtgca aagagaaaag gggcattatc ccgctggatg cacactgctg cgtggaggtg ctgccagacc gcgacggaaa gcgctgcatg ttctgtgtga agacagccac ccgcacgtat gagatgagcg cctcagacac gcgccagcgc caggagtgga cagctgccat ccagatggcg atccggctgc aggccgaggg gaagacgtcc ctacacaagg acctgaagca gaaacggcgc gagcagcggg agcagcggta Protein function: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling. [The UniProt Consortium]