CYP4F11 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 1575 Sequence: atgccgcagc tgagcctgtc ctggctgggc ctcgggcccg tggcagcatc cccgtggctg cttctgctgc tggttggggg ctcctggctc ctggcccgcg tcctggcctg gacctacacc ttctatgaca actgccgccg cctccagtgt tttcctcaac ccccgaaaca gaactggttt tggggacacc agggcctggt cactcccacg gaagagggca tgaagacatt gacccagctg gtgaccacat atccccaggg ctttaagttg tggctgggtc ctaccttccc cctcctcatt ttatgccacc ctgacatcat ccggcctatc accagtgcct cagctgctgt cgcacccaag gatatgattt tctatggctt cctgaagccc tggctggggg atgggctcct gctgagtggt ggtgacaagt ggagccgcca ccgtcggatg ttgacgcctg ccttccattt caacatcttg aagccttata tgaagatttt caacaagagt gtgaacatca tgcacgacaa gtggcagcgc ctggcctcag agggcagcgc cagactggac atgtttgaac acatcagcct catgaccttg gacagtctgc agaaatgtgt cttcagcttt gaaagcaatt gtcaggagaa gcccagtgaa tatattgccg ccatcttgga gctcagtgcc tttgtagaaa agagaaacca gcagattctc ttgcacacgg acttcctgta ttatctcact cctgatgggc agcgcttccg cagggcctgc cacctggtgc acgacttcac agatgccgtc atccaggagc ggcgccgcac cctccccact cagggtattg atgatttcct caagaacaag gcaaagtcca agactttaga cttcattgat gtgcttctgc tgagcaagga tgaagatggg aaggaattgt ctgatgagga cataagagca gaagctgaca ccttcatgtt tgagggccat gacactacag ccagtggtct ctcctgggtc ctataccacc ttgcaaagca cccagaatac caggaacagt gccggcaaga agtgcaagag cttctgaagg accgtgaacc tatagagatt gaatgggacg acctggccca gctgcccttc ctgaccatgt gcattaagga gagcctgcgg ttgcatcccc cagtcccggt catctcccga tgttgcacgc aggactttgt gctcccagac ggccgcgtca tccccaaagg cattgtctgc ctcatcaata ttatcgggat ccattacaac ccaactgtgt ggccagaccc tgaggtctac gaccccttcc gtttcaacca agagaacatc aaggagaggt cacctctggc ttttattccc ttctcggcag ggcccagaaa ctgcatcggg caggcgttcg ccatggctga gatgaaggtg gtcctggcgc tcacgctgct gcacttccgc atcctgccga cccacactga accccgcagg aaacccgagc tgatattgcg cgcagagggt ggactttggc tgcgggtgga gcccctgggt gcgaactcac Protein function: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and their oxygenated derivatives (oxylipins) (PubMed:24138531, PubMed:15364545, PubMed:18065749). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR, NADPH-ferrihemoprotein reductase) (PubMed:15364545, PubMed:18065749, PubMed:24138531). Catalyzes with high efficiency the oxidation of the terminal carbon (omega-oxidation) of 3-hydroxy fatty acids, such as 3-hydroxyhexadecanoic and 3-hydroxyoctadecanoic acids, likely participating in the biosynthesis of long-chain 3- hydroxydicarboxylic acids (PubMed:18065749, PubMed:19932081). Omega- hydroxylates and inactivates phylloquinone (vitamin K1), and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulation (PubMed:24138531). Metabolizes with low efficiciency fatty acids, including (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) and its oxygenated metabolite 8-hydroxyeicosatetraenoic acid (8-HETE) (PubMed:15364545, PubMed:19932081). Catalyzes N- and O- demethylation of drugs such as erythromycin, benzphetamine, ethylmorphine, chlorpromazine, imipramine and verapamil (PubMed:15364545). [The UniProt Consortium]