CYP2U1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1635 Sequence: atgtcgtctc cggggccgtc gcagccgccg gccgaggacc cgccctggcc cgcgcgcctc ctgcgtgcgc ctctggggct gctgcggctg gaccccagcg ggggcgcgct gctgctatgc ggcctcgtag cgctgctggg ctggagctgg ctgcggaggc gccgggcgcg gggcatcccg cccgggccca cgccctggcc tctggtgggc aacttcggtc acgtgctgct gcctcccttc ctccggcggc ggagctggct gagcagcagg accagggccg cagggattga tccctcggtc ataggcccgc aggtgctcct ggctcaccta gcccgcgtgt acggcagcat cttcagcttc tttatcggcc actacctggt ggtggtcctc agcgacttcc acagcgtgcg cgaggcgctg gtgcagcagg ccgaggtctt cagcgaccgc ccgcgggtgc cgctcatctc catcgtgacc aaggagaagg gggttgtgtt tgcacattat ggtcccgtct ggagacaaca aaggaagttc tctcattcaa ctcttcgtca ttttgggttg ggaaaactta gcttggagcc caagattatt gaggagttca aatatgtgaa agcagaaatg caaaagcacg gagaagaccc cttctgccct ttctccatca tcagcaatgc cgtctctaac atcatttgct ccttgtgctt tggccagcgc tttgattaca ctaatagtga gttcaagaaa atgcttggtt ttatgtcacg aggcctagaa atctgtctga acagtcaagt cctcctggtc aacatatgcc cttggcttta ttaccttccc tttggaccat ttaaggaatt aagacaaatt gaaaaggata taaccagttt ccttaaaaaa atcatcaaag accatcaaga gtctctggat agagagaacc ctcaggactt catagacatg taccttctcc acatggaaga ggagaggaaa aataatagta acagcagttt tgatgaagag tacttatttt atatcattgg ggatctcttt attgctggga ctgataccac aactaactct ttgctctggt gcctgctgta tatgtcgctg aaccccgatg tacaagaaaa ggttcatgaa gaaattgaaa gagtcattgg cgccaaccga gctccttccc tcacagacaa ggcccagatg ccctacacag aagccaccat catggaagtg cagaggctaa ctgtggtggt gccgcttgcc attcctcata tgacctcaga gaacacagtg ctccaagggt ataccattcc taaaggcaca ttgatcttac ccaacctgtg gtcagtacat agagacccag ccatttggga gaaaccggag gatttctacc ctaatcgatt tctggatgac caaggacaac taattaaaaa agaaaccttt attccttttg ggatagggaa gcgggtgtgt atgggagaac aactggcaaa gatggaatta ttcctaatgt ttgtgagcct aatgcagagt ttcgcatttg ctttacctga ggattctaag aagcccctcc tgactggaag atttggtcta actttagccc cacatccatt taatataact atttcaagga Protein function: A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates (PubMed:14660610, PubMed:24563460). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR, NADPH- ferrihemoprotein reductase) (PubMed:14660610, PubMed:24563460). Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes (PubMed:14660610, PubMed:24563460). May downregulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin (PubMed:24563460). [The UniProt Consortium]