CYP2S1 (Vector pUC, Accession No. BC033691)

Length: 1515 Sequence: atggaggcga ccggcacctg ggcgctgctg ctggcgctgg cgctgctcct gctgctgacg ctggcgctgt ccgggaccag ggcccgaggc cacctgcccc ccgggcccac gccgctacca ctgctgggaa acctcctgca gctacggccc ggggcgctgt attcagggct catgcggctg agtaagaagt acggaccggt gttcaccatc tacctgggac cctggcggcc tgtggtggtc ctggttgggc aggaggctgt gcgggaggcc ctgggaggtc aggctgagga gttcagcggc cggggaaccg tagcgatgct ggaagggact tttgatggcc atggggtttt cttctccaac ggggagcggt ggaggcagct gaggaagttt accatgcttg ctctgcggga cctgggcatg gggaagcgag aaggcgagga gctgatccag gcggaggccc ggtgtctggt ggagacattc caggggacag aaggacgccc attcgatccc tccctgctgc tggcccaggc cacctccaac gtagtctgct ccctcctctt tggcctccgc ttctcctatg aggataagga gttccaggcc gtggtccggg cagctggtgg taccctgctg ggagtcagct cccagggggg tcagacctac gagatgttct cctggttcct gcggcccctg ccaggccccc acaagcagct cctccaccac gtcagcacct tggctgcctt cacagtccgg caggtgcagc agcaccaggg gaacctggat gcttcgggcc ccgcacgtga ccttgtcgat gccttcctgc tgaagatggc acaggaggaa caaaacccag gcacagaatt caccaacaag aacatgctga tgacagtcat ttatttgctg tttgctggga cgatgacggt cagcaccacg gtcggctata ccctcctgct cctgatgaaa taccctcatg tccaaaagtg ggtacgtgag gagctgaatc gggagctggg ggctggccag gcaccaagcc taggggaccg tacccgcctc ccttacaccg acgcggttct gcatgaggcg cagcggctgc tggcgctggt gcccatggga ataccccgca ccctcatgcg gaccacccgc ttccgagggt acaccctgcc ccagggcacg gaggtcttcc ccctccttgg ctccatcctg catgacccca acatcttcaa gcacccagaa gagttcaacc cagaccgttt cctggatgca gatggacggt tcaggaagca tgaggcgttc ctgcccttct ccttagggaa gcgtgtctgc cttggagagg gcctggcaaa agcggagctc ttcctcttct tcaccaccat cctacaagcc ttctccctgg agagcccgtg cccgccggac accctgagcc tcaagcccac cgtcagtggc cttttcaaca ttcccccagc cttccagctg caagtccgtc ccactgacct tcactccacc acgcagacca Protein function: A cytochrome P450 monooxygenase involved in the metabolism of retinoids and eicosanoids (PubMed:12711469, PubMed:21068195). In epidermis, may contribute to the oxidative metabolism of all-trans- retinoic acid. For this activity, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:12711469). Additionally, displays peroxidase and isomerase activities toward various oxygenated eicosanoids such as prostaglandin H2 (PGH2) and hydroperoxyeicosatetraenoates (HPETEs) (PubMed:21068195). Independently of cytochrome P450 reductase, NADPH, and O2, catalyzes the breakdown of PGH2 to hydroxyheptadecatrienoic acid (HHT) and malondialdehyde (MDA), which is known to act as a mediator of DNA damage (PubMed:21068195). [The UniProt Consortium]