CYP2J2 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1509 Sequence: atgctcgcgg cgatgggctc tctggcggct gccctctggg cagtggtcca tcctcggact ctcctactgg gcactgtcgc ctttctgctc gctgctgact ttctcaaaag acggcgccca aagaactacc cgccggggcc ctggcgcctg cccttccttg gcaacttctt ccttgtggac ttcgagcagt cgcacctgga ggttcagctg tttgtgaaga aatatgggaa cctttttagc ttggagcttg gtgacatatc tgcagttctt attactggct tgcccttaat caaagaagcc cttatccaca tggaccaaaa ctttgggaac cgccccgtga cccctatgcg agaacatatc tttaagaaaa atggattgat tatgtcaagt ggccaggcat ggaaggagca aagaaggttc actctgacag cactaaggaa ctttggttta ggaaagaaga gcttagagga acgcattcag gaggaggccc aacacctcac tgaagcaata aaagaggaga acggacagcc ttttgaccct catttcaaga tcaacaatgc agtttccaat atcatttgct ccatcacctt cggagaacgc tttgagtacc aggatagttg gtttcagcag ctgctgaagt tactagatga agtcacatac ttggaggctt caaagacatg ccagctctac aatgtctttc catggataat gaaattcctg cctggacccc accaaactct cttcagcaac tggaaaaaac tgaaattgtt tgtttctcat atgattgaca aacacagaaa ggattggaat cctgcagaaa caagagactt tattgatgct taccttaaag aaatgtcaaa gcacacaggc aatcctactt caagtttcca tgaagaaaac ctcatctgca gcaccctgga cctcttcttt gccggaaccg agacaacttc cacaactctg cgatgggctc tgctttatat ggccctctac ccagaaatcc aagaaaaagt acaagctgag attgacagag tgattggcca ggggcagcag ccgagcacag ccgcccggga gtccatgccc tacaccaatg ctgtcatcca tgaggtgcag agaatgggca acatcatccc cctgaacgtt cccagggaag tgacagttga taccactttg gctgggtacc acctgcccaa gggtaccatg atcctgacca atttgacggc gctgcacagg gaccccacag agtgggccac ccctgacaca ttcaatccgg accattttct ggagaatgga cagtttaaga aaagggaagc ctttatgcct ttctcaatag gaaagcgggc atgcctcgga gaacagttgg ccaggactga gctgtttatt ttcttcactt cccttatgca aaaatttacc ttcaggcccc caaacaatga gaagctgagc ctgaagttta gaatgggtat caccatttcc ccagtcagtc accgcctctg cgctgttcct Protein function: A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) in the cardiovascular system (PubMed:8631948, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:8631948, PubMed:19965576). Catalyzes the epoxidation of double bonds of PUFA (PubMed:8631948, PubMed:19965576). Converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EpETrE), likely playing a major role in the epoxidation of endogenous cardiac arachidonic acid pools (PubMed:8631948). In endothelial cells, participates in eicosanoids metabolism by converting hydroperoxide species into hydroxy epoxy metabolites. In combination with 15- lipoxygenase metabolizes arachidonic acid and converts hydroperoxyicosatetraenoates (HpETEs) into hydroxy epoxy eicosatrienoates (HEETs), which are precursors of vasodilatory trihydroxyicosatrienoic acids (THETAs). This hydroperoxide isomerase activity is NADPH- and O2-independent (PubMed:19737933). Catalyzes the monooxygenation of a various xenobiotics, such as danazol, amiodarone, terfenadine, astemizole, thioridazine, tamoxifen, cyclosporin A and nabumetone (PubMed:19923256). Catalyzes hydroxylation of the anthelmintics albendazole and fenbendazole (PubMed:23959307). Catalyzes the sulfoxidation of fenbedazole (PubMed:19923256). [The UniProt Consortium]