CXXC5 (Vector pUC, Accession No. BC002490)

Length: 969 Sequence: atgtcgagcc tcggcggtgg ctcccaggat gccggcggca gtagcagcag cagcaccaat ggcagcggtg gcagtggcag cagtggccca aaggcaggag cagcagacaa gagtgcagtg gtggctgccg ccgcaccagc ctcagtggca gatgacacac caccccccga gcgtcggaac aagagcggta tcatcagtga gcccctcaac aagagcctgc gccgctcccg cccgctctcc cactactctt cttttggcag cagtggtggt agtggcggtg gcagcatgat gggcggagag tctgctgaca aggccactgc ggctgcagcc gctgcctccc tgttggccaa tgggcatgac ctggcggcgg ccatggcggt ggacaaaagc aaccctacct caaagcacaa aagtggtgct gtggccagcc tgctgagcaa ggcagagcgg gccacggagc tggcagccga gggacagctg acgctgcagc agtttgcgca gtccacagag atgctgaagc gcgtggtgca ggagcatctc ccgctgatga gcgaggcggg tgctggcctg cctgacatgg aggctgtggc aggtgccgaa gccctcaatg gccagtccga cttcccctac ctgggcgctt tccccatcaa cccaggcctc ttcattatga ccccggcagg tgtgttcctg gccgagagcg cgctgcacat ggcgggcctg gctgagtacc ccatgcaggg agagctggcc tctgccatca gctccggcaa gaagaagcgg aaacgctgcg gcatgtgcgc gccctgccgg cggcgcatca actgcgagca gtgcagcagt tgtaggaatc gaaagactgg ccatcagatt tgcaaattca gaaaatgtga ggaactcaaa aagaagcctt ccgctgctct ggagaaggtg atgcttccga cgggagccgc cttccggtgg Protein function: May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells. Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034). [The UniProt Consortium]