CUL7 (Vector pUC, Accession No. BC033647)

Length: 5097 Sequence: atggtgggag aactccgcta cagggaattc agggtgcccc tggggcccgg cttacatgcc tatcctgatg agctgatccg ccagcgcgtg ggccatgatg ggcatcctga gtaccagatc cgttggctca tcctgcggcg tggcgatgag ggggacgggg gctctggcca agtggactgc aaggctgagc acatcctgct gtggatgtcc aaggatgaga tctatgccaa ctgccacaag atgctgggcg aggatggcca ggtcatcggg ccctcccagg agtctgcagg ggaggttggg gccctggaca aatctgtgct ggaggagatg gaaaccgacg tgaagtccct cattcagaga gcccttcggc agctggagga gtgtgtgggc actatccctc ctgctcctct acttcacact gtccacgtgc tcagcgccta tgccagcatt gagcccctca ctggagtatt caaggaccca agggtcctgg acttgctcat gcacatgttg agtagtcctg attatcagat tcgctggagt gcaggccgga tgatacaagc cctgtcctcc catgacgctg ggacccggac tcagatcctt ctgtcactga gccaacaaga agccattgag aaacacctgg attttgacag ccgctgtgct ctgctagcac tgtttgcaca ggccacgctc tctgaacacc ccatgtcttt cgagggcatt cagctaccac aggtcccagg aagggtgctc ttctccctgg tgaagcggta tttgcatgtc acctcgctcc tggatcagct gaacgacagt gctgcggagc caggagccca gaacacctct gctcctgagg agttgagtgg ggagaggggt caactggagc tggagttcag tatggccatg ggcaccctga tctcggagct ggtgcaagcc atgcgctggg accaggcctc agacagacca aggagctcag cacggtcccc cggttccatc ttccagcctc agctggcaga tgtgagccca gggctccccg ctgcccaggc tcagccctcc ttcaggaggt caagacgttt tcgccctcgt tctgagttcg caagtggcaa tacctatgct ttgtatgtgc gggacacact gcagccgggg atgcgagtgc ggatgctgga tgattatgag gagatcagtg ccggggatga gggcgagttt cggcagagca acaacggtgt gcctcctgtg caggtatttt gggagtcaac aggccgcacc tattgggtgc actggcacat gctggagatc ttgggctttg aggaagacat tgaggacatg gttgaggctg atgagtacca aggggcagtg gccagtagag tcctgggtag agccctgcct gcctggcgct ggaggcccat gacagaactc tatgctgtgc cttatgtgct gcctgaggat gaggacactg aggagtgtga acacctgacc ctggctgagt ggtgggaact cctcttcttc atcaagaagc tggatggacc tgaccatcag gaggttctcc agatcctcca ggagaaccta gatggggaga ttctggatga tgagatccta gctgaactgg ccgtgcccat agaattggcc caggacttgc tgctgactct gccacagcga ctcaatgaca gtgccctcag ggacctgatc aactgccatg tctacaagaa gtatgggcct gaagccctag cagggaacca agcctaccca tcccttctag aagcccaaga agatgtcctc ctgctagacg cgcaggccca ggctaaggac tcagaagatg cagccaaagt ggaagcaaaa gaacccccat ctcagagtcc caacactccc ctgcagcgtc tggtggaggg ttatggtcca gctgggaaaa tcctcctgga tctagagcaa gccctcagct cagaggggac ccaggagaac aaggtcaagc cactcctgct gcagctgcag cggcagccgc agcccttcct ggcactgatg cagagcctgg acactccgga gactaacagg accctgcacc tgactgtgct gagaatcctg aagcagctgg tggacttccc cgaggcactg ctgctcccct ggcacgaggc cgtggatgcc tgcatggcct gcctgcggtc cccaaacact gatcgagagg tgctccagga actgattttc ttcctgcacc gcctgacctc agtgagcagg gactatgccg tggtgctgaa tcagctggga gcaagagacg ctatctccaa ggccctggaa aagcacctgg gaaagctgga gctggctcag gagctgcggg acatggtgtt caagtgtgag aagcatgccc acctctaccg caaactcatc accaacatcc tgggaggctg catccagatg gtgctgggcc agatcgaaga ccacagacga acccaccggc ccatcaacat ccctttcttt gatgtgttcc tcagatacct gtgccagggc tccagtgtgg aagtgaagga ggacaagtgc tgggagaagg tggaggtgtc ctccaacccg caccgggcca gcaagctgac ggaccacaac cccaagacct attgggagtc caacggcagc gccggctccc actacatcac cctgcacatg cgccggggca tcctcatcag gcaactgact ctgcttgtgg ctagtgagga ctcgagttac atgccggccc gagtggtggt gtgcgggggt gatagcacta gctctcttca cacggaactc aactcggtga atgtgatgcc ctctgccagc cgggtgatcc tcctggagaa cctgacccgc ttctggccca tcatccagat ccgcataaag cgctgccagc agggtggcat tgatacgcgc attcgggggt tagagatcct aggccccaag cccacgttct ggccagtgtt ccgggagcag ctctgtcgtc acacacgcct cttctacatg gttcgggcac aggcctggag ccaggacatg gcagaggacc gcaggagcct cctgcacctg agttctagac tcaacggtgc tctgcgccag gagcagaatt ttgctgaccg cttcctccct gatgacgagg ctgcccaagc tctgggcaag acctgctggg aggccctggt cagccccgtg gtgcagaaca tcacctcccc tgatgaggat ggcattagcc ccctgggttg gctgctggac cagtacctgg agtgtcagga agctgtcttc aacccccaga gccgcggccc agctttcttc tcgcgggtgc gccgtctcac tcacctgctg gtgcatgtcg agccctgtga ggcaccccct cctgtggtgg ccactcctcg gcccaaaggc agaaacagaa gccacgactg gagctccttg gctacccggg gccttccaag cagcatcatg agaaacctga cgcgctgttg gcgggccgtg gtggagaagc aggtgaacaa ttttctgacc tcatcctggc gggatgatga ctttgtgcca cgctactgtg agcactttaa tattctgcag aactcaagct ctgaactgtt tgggcctcgg gcagccttct tgctggcgct gcaaaatggc tgtgcgggag ccttgctgaa gctccctttt ctcaaagctg cccacgtgag tgagcagttc gcccggcaca ttgaccagca gatccagggc agccggatcg gtggagccca ggaaatggag aggctggcac agctgcagca atgcctgcaa gctgtcctga ttttctccgg cttggagata gccaccactt ttgagcatta ttaccagcac tacatggcgg accgtctcct gggcgtggtc tcgagctggc tggagggggc cgtgctggag cagatcggtc cctgcttccc caaccgcctc ccccagcaga tgttgcagag cctgagcacc tctaaggagc tgcagcgcca gttccacgtc taccagctcc agcagctgga tcaggaactc ctgaagctgg aggatacaga gaagaaaata caggtgggcc ttggggccag tggcaaggag cacaagagcg agaaggaaga ggaagctggg gcagcagcag tggtggatgt ggcggaggga gaggaggaag aggaggagaa tgaggacctc tactatgaag gggcaatgcc agaagtgtct gtgcttgtcc tgtcccgaca ctcctggcct gttgcctcaa tctgccacac actgaacccc agaacctgcc tgccctccta cctgaggggc actttgaaca gatactccaa cttctacaac aagagtcaga gccaccctgc ccttgagcga ggctcacaga ggcgactgca gtggacgtgg ctgggctggg ctgagctgca gtttgggaac cagaccctgc atgtgtccac cgtgcagatg tggctactgc tgtatctcaa cgacctgaag gcggtctctg tggagagtct gctggcgttc tcagggctct ccgcagacat gctcaatcag gcgattgggc ccctcacctc ttcaagaggc cccctggacc ttcacgagca aaaggatata ccaggagggg tcctcaagat tcgagatggc agcaaggaac ccaggtcgag atgggacatt gtgcggctca tcccacctca gacgtacctg caagctgagg gtgaagacgg ccagaacttg gagaagagac ggaatcttct gaactgcctc atcgtccgaa tcctcaaggc ccatggagat gaggggctgc acattgacca gcttgtctgt ctggtgctgg aggcttggca gaagggcccg tgtcctccca ggggtttggt cagcagcctt ggtaaggggt ctgcatgcag cagcactgac gtcctctcct gcatcctaca cctcctgggc aagggcacgc tgagacgcca tgacgaccgg ccccaggtgc tgtcctatgc agtccctgtg actgtcatgg agcctcacac tgagtccctg aacccaggct cctcaggccc caacccaccc ctcaccttcc ataccctaca gattcgctcc cggggtgtgc cctatgcctc ctgcactgcc acccagagct tctctacctt Protein function: Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695). Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 (PubMed:24793696). Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1 (PubMed:21572988, PubMed:24362026). Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Acts as a regulator in trophoblast cell epithelial-mesenchymal transition and placental development (PubMed:20139075). Does not promote polyubiquitination and proteasomal degradation of p53/TP53 (PubMed:16547496, PubMed:17332328). While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may be have additional functions. [The UniProt Consortium]