CTCFL (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1992 Sequence: atggcagcca ctgagatctc tgtcctttct gagcaattca ccaagatcaa agaactcgag ttgatgccgg aaaaaggcct gaaggaggag gaaaaagacg gagtgtgcag agagaaagac catcggagcc ctagtgagtt ggaggccgag cgtacctctg gggccttcca ggacagcgtc ctggaggaag aagtggagct ggtgctggcc ccctcggagg agagcgagaa gtacatcctg accctgcaga cggtgcactt cacttctgaa gctgtggagt tgcaggatat gagcttgctg agcatacagc agcaagaagg ggtgcaggtg gtggtgcaac agcctggccc tgggttgctg tggcttgagg aagggccccg gcagagcctg cagcagtgtg tggccattag tatccagcaa gagctgtact ccccgcaaga gatggaggtg ttgcagttcc acgctctaga ggagaatgtg atggtggcca gtgaagacag taagttagcg gtgagcctgg ctgaaactgc tggactgatc aagctcgagg aagagcagga gaagaaccag ttattggctg aaagaacaaa ggagcagctc ttttttgtgg aaacaatgtc aggagatgaa agaagtgacg aaattgttct cacagtttca aattcaaatg tggaagaaca agaggatcaa cctacagctg gtcaagcaga tgctgaaaag gccaaatcta caaaaaatca aagaaagaca aagggagcaa aaggaacctt ccactgtgat gtctgcatgt tcacctcttc tagaatgtca agttttaatc gtcatatgaa aactcacacc agtgagaagc ctcacctgtg tcacctctgc ctgaaaacct tccgtacggt cactctgctg cggaaccatg ttaacaccca cacaggaacc aggccctaca agtgtaacga ctgcaacatg gcatttgtca ccagtggaga actcgtccga cacaggcgct ataaacatac tcatgagaaa ccctttaaat gttccatgtg caagtatgcc agtgtggagg caagtaaatt gaagcgccat gtccgatccc acactgggga gcgccccttt cagtgttgcc agtgcagcta tgccagcaga gacacctaca agctgaaacg ccacatgaga acgcactcag gtgagaagcc ttacgaatgc cacatctgcc acacccgctt cacccagagc gggaccatga aaatacatat tctgcagaaa cacggcgaaa atgtccccaa ataccagtgt ccccattgtg ccaccatcat tgcacggaaa agcgacctac gtgtgcatat gcgcaacttg catgcttaca gcgctgcaga gctgaaatgc cgctactgtt ctgctgtctt ccatgaacgc tatgccctca ttcagcacca gaaaactcat aagaatgaga agaggttcaa gtgcaaacac tgcagttatg cctgcaagca ggaacgtcat atgaccgctc acattcgtac ccacactgga gagaaaccat tcacctgcct ttcttgcaat aaatgtttcc gacagaagca acttctaaac gctcacttca ggaaatacca cgatgcaaat ttcatcccga ctgtttacaa atgctccaag tgtggcaaag gcttttcccg ctggattaac ctgcacagac attcggagaa gtgtggatca ggggaagcaa agtcggctgc ttcaggaaag ggaagaagaa caagaaagag gaagcagacc atcctgaagg aagccacaaa gggtcagaag gaagctgcga agggatggaa ggaagccgcg aacggagacg aagctgctgc tgaggaggct tccaccacga agggagaaca gttcccagga gagatgtttc ctgtcgcctg cagagaaacc acagccagag tcaaagagga agtggatgaa ggcgtgacct gtgaaatgct cctcaacacg atggataagt Protein function: Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites. Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters. [The UniProt Consortium]