CPEB4 (Vector pUC, Accession No. BC036899)

Length: 969 Sequence: atgcactcac tggagagttc actcattgac ataatgagag ctgaaaatga taccattaaa ggtcagtctt cactgtttcc aatggaagat ggattcttgg atgatggccg tggggatcag cctcttcata gtggcctggg ttcacctcac tgcttcagtc accagaatgg ggaaagagtg gaacgatatt ctcgaaaggt gtttgtaggc ggattgcctc cagacattga tgaagatgag atcacagcta gttttcgtcg ctttggccct ctgattgtgg attggcctca taaagctgag agcaaatcct attttcctcc taaaggctat gcattcctgc tgtttcaaga tgaaagctct gtgcaggctc tcattgatgc atgcattgaa gaagatggaa aactctacct ttgtgtatca agtcccacta tcaaggataa gccagtccag attcggcctt ggaatctcag tgacagtgac tttgtgatgg atggttcaca gccacttgac ccacgaaaaa ctatatttgt tggtggtgtt cctcgaccat tacgagctgt ggagcttgcg atgataatgg atcggctata tggaggtgtg tgctacgctg ggattgatac cgaccctgag ctaaaatacc caaaaggagc tgggagagtt gcgttctcta atcaacagag ttacatagct gctatcagtg cccgctttgt tcagctgcag catggagaga tagataaacg ggtggaagtt aagccatatg tcttggatga tcagctgtgt gatgaatgtc agggggcccg ttgtgggggg aaatttgctc catttttctg tgctaatgtt acctgtctgc agtattactg tgaatattgc tgggctgcta tccattctcg tgctggcagg gaattccaca agcccctggt gaaggaaggc ggtgaccgcc ctcggcatat ttcattccgc Protein function: Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR (PubMed:24990967). RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (PubMed:24990967). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE- regulated mRNAs in conditions in which global protein synthesis is inhibited. Required for cell cycle progression, specifically for cytokinesis and chromosomal segregation (PubMed:26398195). Plays a role as an oncogene promoting tumor growth and progression by positively regulating translation of t-plasminogen activator/PLAT (PubMed:22138752). Stimulates proliferation of melanocytes (PubMed:27857118). In contrast to CPEB1 and CPEB3, does not play role in synaptic plasticity, learning and memory. [The UniProt Consortium]