CPEB3 (Vector pUC, Accession No. BC036444)

Length: 2094 Sequence: atgcaggatg atttactgat ggacaaaagc aaaacccagc cccagcccca gcagcagcag cggcagcagc agcagcccca acctgagtcc agcgtatccg aagccccgtc cacgcccctc tcctcagaga cccccaagcc ggaggaaaac agcgcagtgc cggccctcag cccagccgct gcccccccgg cccccaacgg cccggacaag atgcagatgg aatcaccgct cctgccaggc ttgagtttcc atcagccccc tcagcagccg ccgccgcctc aggagcccgc ggcaccgggc gcgtcgctgt cgccgtcctt cggcagcacc tggtccacgg gcaccaccaa cgcggtagag gacagcttct tccaggggat caccccagtc aacgggacca tgctcttcca gaacttcccg caccatgtca acccagtctt cggaggcact ttctccccgc agatcggcct ggcgcagacc cagcaccacc agcagccgcc gccgcctgcg cccgcgccgc agccggcaca gccagcgcag ccacctcagg cgcagccccc gcagcagcgc cgctcacccg ccagccccag ccaggcgccc tacgcgcaga ggagcgccgc cgcggcgtac ggccaccagc ccatcatgac cagcaagccg tcctcgtctt cggcggttgc agccgctgct gccgcagccg ccgcctcgtc ggcctcgtcc agctggaaca cgcaccaaag cgtgaatgca gcctggagcg caccgtccaa cccctggggc ggcctgcagg cgggccggga ccctcgccgg gcggtcggtg tgggcgtggg tgtgggtgtc ggggtgcctt ccccgctcaa ccccatctcg ccgctcaaaa agcccttctc cagcaacgtg atcgcgccgc ccaagttccc tcgcgcggcc cctctcactt ccaagtcctg gatggaggat aacgctttct ggaccgataa tggtaacaat ctgttgccat ttcaggaccg gagtaggccc tatgatactt ttaacttgca ctcgttggag aactccttaa tggatatgat aaggactgat catgaacctc tgaaaggtaa acactaccct cccagtggcc caccaatgag tttcgctgat ataatgtgga ggaatcattt tgcaggacgc atggggataa atttccatca tccaggaaca gataatatta tggcacttaa caatgccttc ctggatgata gccatggtga tcaagccttg tcatctggct taagttctcc cactcgctgt caaaatgggg aacgagtaga acgctactct agaaaggtgt ttgttggagg acttcctcct gatattgatg aagatgagat cactgccagc tttcgcaggt ttggacctct cgtagtagac tggcctcaca aagctgaaag caagtcttat tttcctccta aaggctatgc ctttctgctg ttccaagagg aaagctcagt acaagctttg atagatgcct gcctagaaga agatgggaaa ctctacctgt gtgtgtcaag ccccatcaag gacaagccag tgcaaattcg accatggaac ctaagtgaca gtgactttgt aatggatggt tctcagcctt tggaccccag aaaaactatc tttgttgggg gagttccacg accccttcga gctgttgaac tggcaatgat catggaccgt ttgtacggtg gtgtctgcta tgctggcatt gatacggacc cagagctgaa gtaccccaaa ggtgctggcc gcgtggcatt ctccaatcag cagagttaca ttgcagccat cagcgctcgt tttgtgcagc ttcagcacaa tgacattgac aaacgggttg aagtaaagcc atatgtgctg gatgatcaga tgtgtgatga gtgccagggc acacgctgtg gtgggaagtt tgccccgttc ttctgtgcca acgtcacctg tctgcagtat tactgtgaat actgctgggc gagcatacat tcccgagccg ggcgggagtt ccacaaaccg ctggtgaagg agggaggcga ccgccctcgt cacgtcccgt tccgctggag Protein function: Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator. In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure. Required for the consolidation and maintenance of hippocampal-based long term memory. In the basal state, binds to the mRNA 3'-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation. Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B. When activated, acts as a translational activator of GRIA1 and GRIA2. In the basal state, suppresses SUMO2 translation but activates it following neuronal stimulation. Binds to the 3'-UTR of TRPV1 mRNA and represses TRPV1 translation which is required to maintain normal thermoception. Binds actin mRNA, leading to actin translational repression in the basal state and to translational activation following neuronal stimulation. Negatively regulates target mRNA levels by binding to TOB1 which recruits CNOT7/CAF1 to a ternary complex and this leads to target mRNA deadenylation and decay (PubMed:21336257). In addition to its role in translation, binds to and inhibits the transcriptional activation activity of STAT5B without affecting its dimerization or DNA-binding activity. This, in turn, represses transcription of the STAT5B target gene EGFR which has been shown to play a role in enhancing learning and memory performance (PubMed:20639532). In contrast to CPEB1, CPEB2 and CPEB4, not required for cell cycle progression (PubMed:26398195). [The UniProt Consortium]