COPS4 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1221 Sequence: atggcggcag ccgtgcgaca ggatttggcc cagctcatga attcgagcgg ctctcataaa gatctggctg gcaagtatcg tcagatcctg gaaaaagcca ttcagttatc tggagcagaa caactagaag ctttgaaagc ttttgtggaa gcaatggtaa atgagaatgt cagtctcgtg atctcgcggc agttgctgac tgatttttgc acacatcttc ctaacttgcc tgatagcaca gccaaagaaa tctatcactt caccttggaa aagatccagc ctagagtcat ttcatttgag gagcaggttg cttccataag acagcatctt gcatctatat atgagaaaga agaagattgg agaaatgcag cccaagtgtt ggtgggaatt cctttggaaa caggacaaaa acagtacaat gtagattata aactggagac ttacttgaag attgctaggc tatatctgga ggatgatgat ccagtccagg cagaggctta cataaatcga gcatcgttgc ttcagaatga atcaaccaat gaacaattac agatacatta taaggtatgc tatgcacgtg ttcttgatta tagaagaaaa ttcattgaag ctgcacaaag gtacaatgag ctctcttaca agacaatagt ccacgaaagt gaaagactag aggccttaaa acatgctttg cactgtacga tcttagcatc agcagggcag cagcgttctc ggatgctagc tactcttttt aaggatgaaa ggtgccagca acttgctgcc tatgggatcc tagagaaaat gtatctagat aggatcatca gaggaaatca acttcaagaa tttgctgcca tgctgatgcc tcaccaaaaa gcaactacag ctgatggttc cagcatcttg gacagagctg ttattgaaca caatttgttg tctgcaagca aattatataa taatattacc ttcgaagaac ttggagctct tttagagatc cctgcagcta aggcggaaaa gatagcatct caaatgataa ccgaaggacg tatgaatgga tttattgacc agattgatgg aatagttcat tttgaaacac gagaagccct gccaacgtgg gataagcaga tccaatcact ttgtttccaa gtgaataacc ttttggagaa aattagtcaa acagcaccag aatggacagc acaagccatg gaagcccaga tggctcagtg Protein function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. [The UniProt Consortium]