COPS2 (Vector pENTR223.1, Accession No. BC012629)

Length: 1332 Sequence: atgtctgaca tggaggatga tttcatgtgc gatgatgagg aggactacga cctggaatac tctgaagata gtaactccga gccaaatgtg gatttggaaa atcagtacta taattccaaa gcattaaaag aagatgaccc aaaagcggca ttaagcagtt tccaaaaggt tttggaactt gaaggtgaaa aaggagaatg gggatttaaa gcactgaaac aaatgattaa gattaacttc aagttgacaa actttccaga aatgatgaat agatataagc agctattgac ctatattcgg agtgcagtca caagaaatta ttctgaaaaa tccattaatt ctattcttga ttatatctct acttctaaac agatggattt actgcaggaa ttctatgaaa caacactgga agctttgaaa gatgctaaga atgatagact gtggtttaag acaaacacaa agcttggaaa attatattta gaacgagagg aatatggaaa gcttcaaaaa attttacgcc agttacatca gtcgtgccag actgatgatg gagaagatga tctgaaaaaa ggtacacagt tattagaaat atatgctttg gaaattcaaa tgtacacagc acagaaaaat aacaaaaaac ttaaagcact ctatgaacag tcacttcaca tcaagtctgc catccctcat ccactgatta tgggagttat cagagaatgt ggtggtaaaa tgcacttgag ggaaggtgaa tttgaaaagg cacacactga tttttttgaa gccttcaaga attatgatga atctggaagt ccaagacgaa ccacttgctt aaaatatttg gtcttagcaa atatgcttat gaaatcggga ataaatccat ttgactcaca ggaggccaag ccgtacaaaa atgatccaga aattttagca atgacgaatt tagtaagtgc ctatcagaat aatgacatca ctgaatttga aaagattcta aaaacaaatc acagcaacat catggatgat cctttcataa gagaacacat tgaagagctt ttgcgaaaca tcagaacaca agtgcttata aaattaatta agccttacac aagaatacat attcctttta tttctaagga gttaaacata gatgtagctg atgtggagag cttgctggtg cagtgcatat tggataacac tattcatggc cgaattgatc aagtcaacca actccttgaa ctggatcatc agaagagggg tggtgcacga tatactgcac tagataaatg gaccaaccaa ctaaattctc tcaaccaggc tgtagtcagt aaactggctt Protein function: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. [The UniProt Consortium]