COPB1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 2862 Sequence: atgacggcgg ctgagaacgt atgctacacg ttaattaacg tgccaatgga ttcagaacca ccatctgaaa ttagcttaaa aaatgatcta gaaaaaggag atgtaaagtc aaagactgaa gctttgaaga aagtaatcat tatgattctg aatggtgaaa aacttcctgg acttctgatg accatcattc gttttgtgct acctcttcag gatcacacta tcaagaaatt acttctggta ttttgggaaa ttgttcctaa aacaactcca gatgggagac ttttacatga gatgatcctt gtatgtgatg catacagaaa ggatcttcaa catcctaatg aatttattcg aggatctact cttcgttttc tttgcaaatt gaaagaagca gaattgctag aacctttaat gccagctatt cgtgcatgtt tggagcatcg acacagctat gttagaagaa atgctgtttt ggccatctat accatctata gaaattttga acatcttata cctgatgctc ctgaactgat acatgatttt ctggtgaatg agaaggatgc aagttgcaaa aggaatgcat ttatgatgct aattcatgca gatcaggatc gagctttgga ttacttaagt acttgcattg atcaagttca aacatttgga gacattctgc agctggttat tgttgaactg atttataagg tctgtcatgc taatccatca gaaagagctc gttttattcg ctgcatctat aacttattac agtcatccag ccctgctgta aaatatgaag ctgctgggac attagtgaca ctctctagtg caccaactgc aatcaaggct gctgctcagt gttacattga tttaattatt aaggagagcg acaacaatgt aaaactcata gttttggatc gcttgataga attaaaagag catcctgctc atgaacgagt actacaggat ctggttatgg atatcctaag agtattgagc acaccagact tagaagtacg aaagaaaact ctgcagttag cactggatct tgtctcttct agaaatgttg aagagctggt tattgtcctg aagaaggaag tgataaaaac aaataatgtg tctgagcatg aagatactga caaatacaga caactcctag tgcgaacatt gcattcctgt tctgtccgat ttccagatat ggctgcaaat gttattcctg tgttaatgga atttctcagt gacaacaacg aagcagcagc tgctgatgtc ttggagtttg ttcgtgaagc cattcagcgc tttgataacc tgagaatgct tattgttgag aagatgcttg aagtctttca tgctattaaa tctgtcaaga tttaccgagg agcattatgg atcctgggag aatactgtag taccaaggaa gacattcaga gtgtgatgac tgagatccgc aggtcccttg gagagatccc aattgtagag tcagaaataa agaaagaagc tggtgaatta aaacctgaag aagaaataac tgtagggcca gttcagaaat tggttactga aatgggtacc tatgcaactc agagtgccct tagcagttct agacccacca agaaagagga agacagacct cccttgagag gattccttct ggatggagat ttctttgttg ctgcctccct tgccacaact ctgaccaaga ttgcattgcg ctatgtagct ttggttcagg agaagaaaaa gcaaaattct tttgttgctg aggctatgtt gctcatggct actatcctgc atttgggaaa atcctctctt cctaagaagc caattactga tgatgatgtg gatcgaattt ccctgtgcct caaggtcttg tctgaatgtt cacctttaat gaatgacatt ttcaataagg aatgcagaca gtccctttct cacatgttat ctgctaaact agaagaagag aaattatccc aaaagaaaga atctgaaaag aggaatgtga cagtacagcc tgatgacccc atttccttca tgcaactaac tgctaagaat gaaatgaact gcaaggaaga tcagtttcag ctgagtttac tggcagcaat gggtaacaca cagaggaaag aggcagcaga tcccctagca tctaaactta acaaggtcac ccaattgaca ggtttctcag atcctgtata tgcagaagct tacgttcatg tcaaccaata tgatattgtc ctggatgtac ttgttgtgaa ccaaaccagt gatactttgc agaattgcac attagaacta gctacactag gggatctgaa acttgtggaa aagccgtctc ctttgactct tgctcctcat gacttcgcaa atattaaagc taacgtcaaa gtagcatcaa cagaaaatgg aataattttt ggtaatatag tttatgatgt ctctggagca gcaagtgaca gaaattgtgt ggttctcagt gatattcaca tcgacatcat ggactatatc cagcctgcaa cttgcactga tgcagaattc cgtcagatgt gggccgaatt tgaatgggaa aacaaagtga cagttaacac caacatggtt gatttaaatg actacttaca gcacatatta aagtcaacca atatgaaatg cctgactcca gaaaaggccc tttctggtta ctgtggcttt atggcagcca acctttatgc tcgttccata tttggtgaag atgcacttgc aaatgtcagc attgagaagc caattcacca gggaccagat gctgctgtta ccggccatat aagaattcgt gcaaagagcc agggaatggc cttaagtctt ggagataaaa tcaacttgtc acagaagaaa actagtatat Protein function: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins, the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation of these proteins. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte surface triglyceride lipase (PNPLA2) with the lipid droplet to mediate lipolysis. Involved in the Golgi disassembly and reassembly processes during cell cycle. Involved in autophagy by playing a role in early endosome function. Plays a role in organellar compartmentalization of secretory compartments including endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC), Golgi, trans-Golgi network (TGN) and recycling endosomes, and in biosynthetic transport of CAV1. Promotes degradation of Nef cellular targets CD4 and MHC class I antigens by facilitating their trafficking to degradative compartments. [The UniProt Consortium]