COMP (Vector pUC, Accession No. BC125092)

Length: 2274 Sequence: ATGGTCCCCG ACACCGCCTG CGTTCTTCTG CTCACCCTGG CTGCCCTCGG CGCGTCCGGA CAGGGCCAGA GCCCGTTGGG CTCAGACCTG GGCCCGCAGA TGCTTCGGGA ACTGCAGGAA ACCAACGCGG CGCTGCAGGA CGTGCGGGAG CTGCTGCGGC AGCAGGTCAG GGAGATCACG TTCCTGAAAA ACACGGTGAT GGAGTGTGAC GCGTGCGGGA TGCAGCAGTC AGTACGCACC GGCCTACCCA GCGTGCGGCC CCTGCTCCAC TGCGCGCCCG GCTTCTGCTT CCCCGGCGTG GCCTGCATCC AGACGGAGAG CGGCGCGCGC TGCGGCCCCT GCCCCGCGGG CTTCACGGGC AACGGCTCGC ACTGCACCGA CGTCAACGAG TGCAACGCCC ACCCCTGCTT CCCCCGAGTC CGCTGTATCA ACACCAGCCC GGGGTTCCGC TGCGAGGCTT GCCCGCCGGG GTACAGCGGC CCCACCCACC AGGGCGTGGG GCTGGCTTTC GCCAAGGCCA ACAAGCAGGT TTGCACGGAC ATCAACGAGT GTGAGACCGG GCAACATAAC TGCGTCCCCA ACTCCGTGTG CATCAACACC CGGGGCTCCT TCCAGTGCGG CCCGTGCCAG CCCGGCTTCG TGGGCGACCA GGCGTCCGGC TGCCAGCGGC GCGCACAGCG CTTCTGCCCC GACGGCTCGC CCAGCGAGTG CCACGAGCAT GCAGACTGCG TCCTAGAGCG CGATGGCTCG CGGTCGTGCG TGTGTGCCGT TGGCTGGGCC GGCAACGGGA TCCTCTGTGG TCGCGACACT GACCTAGACG GCTTCCCGGA CGAGAAGCTG CGCTGCCCGG AGCGCCAGTG CCGTAAGGAC AACTGCGTGA CTGTGCCCAA CTCAGGGCAG GAGGATGTGG ACCGCGATGG CATCGGAGAC GCCTGCGATC CGGATGCCGA CGGGGACGGG GTCCCCAATG AAAAGGACAA CTGCCCGCTG GTGCGGAACC CAGACCAGCG CAACACGGAC GAGGACAAGT GGGGCGATGC GTGCGACAAC TGCCGGTCCC AGAAGAACGA CGACCAAAAG GACACAGACC AGGACGGCCG GGGCGATGCG TGCGACGACG ACATCGACGG CGACCGGATC CGCAACCAGG CCGACAACTG CCCTAGGGTA CCCAACTCAG ACCAGAAGGA CAGTGATGGC GATGGTATAG GGGATGCCTG TGACAACTGT CCCCAGAAGA GCAACCCGGA TCAGGCGGAT GTGGACCACG ACTTTGTGGG AGATGCTTGT GACAGCGATC AAGACCAGGA TGGAGACGGA CATCAGGACT CTCGGGACAA CTGTCCCACG GTGCCTAACA GTGCCCAGGA GGACTCAGAC CACGATGGCC AGGGTGATGC CTGCGACGAC GACGACGACA ATGACGGAGT CCCTGACAGT CGGGACAACT GCCGCCTGGT GCCTAACCCC GGCCAGGAGG ACGCGGACAG GGACGGCGTG GGCGACGTGT GCCAGGACGA CTTTGATGCA GACAAGGTGG TAGACAAGAT CGACGTGTGT CCGGAGAACG CTGAAGTCAC GCTCACCGAC TTCAGGGCCT TCCAGACAGT CGTGCTGGAC CCGGAGGGTG ACGCGCAGAT TGACCCCAAC TGGGTGGTGC TCAACCAGGG AAGGGAGATC GTGCAGACAA TGAACAGCGA CCCAGGCCTG GCTGTGGGTT ACACTGCCTT CAATGGCGTG GACTTCGAGG GCACGTTCCA TGTGAACACG GTCACGGATG ACGACTATGC GGGCTTCATC TTTGGCTACC AGGACAGCTC CAGCTTCTAC GTGGTCATGT GGAAGCAGAT GGAGCAAACG TATTGGCAGG CGAACCCCTT CCGTGCTGTG GCCGAGCCTG GCATCCAACT CAAGGCTGTG AAGTCTTCCA CAGGCCCCGG GGAACAGCTG CGGAACGCTC TGTGGCATAC AGGAGACACA GAGTCCCAGG TGCGGCTGCT GTGGAAGGAC CCGCGAAACG TGGGTTGGAA GGACAAGAAG TCCTATCGTT GGTTCCTGCA GCACCGGCCC CAAGTGGGCT ACATCAGGGT GCGATTCTAT GAGGGCCCTG AGCTGGTGGC CGACAGCAAC GTGGTCTTGG ACACAACCAT GCGGGGTGGC CGCCTGGGGG TCTTCTGCTT CTCCCAGGAG AACATCATCT GGGCCAACCT GCGTTACCGC TGCAATGACA CCATCCCAGA GGACTATGAG ACCCATCAGC TGCGGCAAGC Protein function: May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7. [The UniProt Consortium]