CNGA3 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 2085 Sequence: ATGGCCAAGA TCAACACCCA ATACTCCCAC CCCTCCAGGA CCCACCTCAA GGTAAAGACC TCAGACCGAG ATCTCAATCG CGCTGAAAAT GGCCTCAGCA GAGCCCACTC GTCAAGTGAG GAGACATCGT CAGTGCTGCA GCCGGGGATC GCCATGGAGA CCAGAGGACT GGCTGACTCC GGGCAGGGCT CCTTCACCGG CCAGGGGATC GCCAGGCTGT CGCGCCTCAT CTTCTTGCTG CGCAGGTGGG CTGCCAGGCA TGTGCACCAC CAGGACCAGG GACCGGACTC TTTTCCTGAT CGTTTCCGTG GAGCCGAGCT TAAGGAGGTG TCCAGCCAAG AAAGCAATGC CCAGGCAAAT GTGGGCAGCC AGGAGCCAGC AGACAGAGGG AGAAGCGCCT GGCCCCTGGC CAAATGCAAC ACTAACACCA GCAACAACAC GGAGGAGGAG AAGAAGACGA AAAAGAAGGA TGCGATCGTG GTGGACCCGT CCAGCAACCT GTACTACCGC TGGCTGACCG CCATCGCCCT GCCTGTCTTC TATAACTGGT ATCTGCTTAT TTGCAGGGCC TGTTTCGATG AGCTGCAGTC CGAGTACCTG ATGCTGTGGC TGGTCCTGGA CTACTCGGCA GATGTCCTGT ATGTCTTGGA TGTGCTTGTA CGAGCTCGGA CAGGTTTTCT CGAGCAAGGC TTAATGGTCA GTGATACCAA CAGGCTGTGG CAGCATTACA AGACGACCAC GCAGTTCAAG CTGGATGTGT TGTCCCTGGT CCCCACCGAC CTGGCTTACT TAAAGGTGGG CACAAACTAC CCAGAAGTGA GGTTCAACCG CCTACTGAAG TTTTCCCGGC TCTTTGAATT CTTTGACCGC ACAGAGACAA GGACCAACTA CCCCAATATG TTCAGGATTG GGAACTTGGT CTTGTACATT CTCATCATCA TCCACTGGAA TGCCTGCATC TACTTTGCCA TTTCCAAGTT CATTGGTTTT GGGACAGACT CCTGGGTCTA CCCAAACATC TCAATCCCAG AGCATGGGCG CCTCTCCAGG AAGTACATTT ACAGTCTCTA CTGGTCCACC TTGACCCTTA CCACCATTGG TGAGACCCCA CCCCCCGTGA AAGATGAGGA GTATCTCTTT GTGGTCGTAG ACTTCTTGGT GGGTGTTCTG ATTTTTGCCA CCATTGTGGG CAATGTGGGC TCCATGATCT CGAATATGAA TGCCTCACGG GCAGAGTTCC AGGCCAAGAT TGATTCCATC AAGCAGTACA TGCAGTTCCG CAAGGTCACC AAGGACTTGG AGACGCGGGT TATCCGGTGG TTTGACTACC TGTGGGCCAA CAAGAAGACG GTGGATGAGA AGGAGGTGCT CAAGAGCCTC CCAGACAAGC TGAAGGCTGA GATCGCCATC AACGTGCACC TGGACACGCT GAAGAAGGTT CGCATCTTCC AGGACTGTGA GGCAGGGCTG CTGGTGGAGC TGGTGCTGAA GCTGCGACCC ACTGTGTTCA GCCCTGGGGA TTATATCTGC AAGAAGGGAG ATATTGGGAA GGAGATGTAC ATCATCAACG AGGGCAAGCT GGCCGTGGTG GCTGATGATG GGGTCACCCA GTTCGTGGTC CTCAGCGATG GCAGCTACTT CGGGGAGATC AGCATTCTGA ACATCAAGGG GAGCAAGTCG GGGAACCGCA GGACGGCCAA CATCCGCAGC ATTGGCTACT CAGACCTGTT CTGCCTCTCA AAGGACGATC TCATGGAGGC CCTCACCGAG TACCCCGAAG CCAAGAAGGC CCTGGAGGAG AAAGGACGGC AGATCCTGAT GAAAGACAAC CTGATCGATG AGGAGCTGGC CAGGGCGGGC GCGGACCCCA AGGACCTTGA GGAGAAAGTG GAGCAGCTGG GGTCCTCCCT GGACACCCTG CAGACCAGGT TTGCACGCCT CCTGGCTGAG TACAACGCCA CCCAGATGAA GATGAAGCAG CGTCTCAGCC AACTGGAAAG CCAGGTGAAG GGTGGTGGGG ACAAGCCCCT GGCTGATGGG GAAGTTCCCG GGGATGCTAC AAAAACAGAG GACAAACAAC Protein function: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. [The UniProt Consortium]