CMPK2 (Vector pUC, Accession No. BC141802)

Length: 1230 Sequence: ATGGCCTTCG CCCGCCGGCT CCTGCGCGGG CCACTGTCGG GGCCGCTGCT CGGGCGGCGC GGGGTCTGCG CTGGGGCCAT GGCTCCGCCG CGCCGCTTCG TCCTGGAGCT TCCCGACTGC ACCCTGGCTC ACTTCGCCCT AGGCGCCGAC GCCCCCGGCG ACGCAGACGC CCCCGACCCC CGCCTGGCGG CGCTGCTGGG GCCCCCGGAG CGCAGCTACT CGCTGTGCGT GCCCGTGACC CCGGACGCCG GCTGCGGGGC CCGGGTCCGG GCGGCGCGGC TGCACCAGCG CCTGCTGCAC CAGCTGCGCC GCGGCCCCTT CCAGCGGTGC CAGCTGCTCA GGCTGCTCTG CTACTGCCCG GGCGGCCAGG CCGGCGGCGC ACAGCAAGGC TTCCTGCTGC GCGACCCCCT GGATGACCCT GACACCCGGC AAGCGCTGCT CGAGCTGCTG GGCGCCTGCC AGGAGGCACC ACGCCCGCAC TTGGGCGAGT TCGAGGCCGA CCCGCGCGGC CAGCTGTGGC AGCGCCTCTG GGAGGTGCAA GACGGCAGGC GGCTGCAGGT GGGCTGCGCA CAGGTCGTGC CCGTCCCGGA GCCCCCGCTG CACCCGGTGG TGCCAGACTT GCCCAGTTCC GTGGTCTTCC CGGACCGGGA AGCCGCCCGG GCCGTTTTGG AGGAGTGTAC CTCCTTTATT CCTGAAGCCC GGGCAGTGCT TGACCTGGTC GACCAGTGCC CAAAACAGAT CCAGAAAGGA AAGTTCCAGG TTGTTGCCAT CGAAGGACTG GATGCCACGG GTAAAACCAC GGTGACCCAG TCAGTGGCAG ATTCACTTAA GGCTGTCCTC TTAAAGTCAC CACCCTCTTG CATTGGCCAG TGGAGGAAGA TCTTTGATGA TGAACCAACT ATCATTAGAA GAGCTTTTTA CTCTTTGGGC AATTATATTG TGGCCTCCGA AATAGCTAAA GAATCTGCCA AATCTCCTGT GATTGTAGAC AGGTACTGGC ACAGCACGGC CACCTATGCC ATAGCCACTG AGGTGAGTGG GGGTCTCCAG CACCTGCCCC CAGCCCATCA CCCTGTGTAC CAGTGGCCAG AGGACCTGCT CAAACCTGAC CTTATCCTGC TGCTCACTGT GAGTCCTGAG GAGAGGTTGC AGAGGCTGCA GGGCCGGGGC ATGGAGAAGA CCAGGGAAGA AGCAGAACTT GAGGCCAACA GTGTGTTTCG Protein function: May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP, CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity. [The UniProt Consortium]