CLK3 (Vector pENTR223.1, Accession No. BC019881)

Length: 1473 Sequence: atgcatcact gtaagcgata ccgctcccct gaaccagacc cgtacctgag ctaccgatgg aagaggagga ggtcctacag tcgggaacat gaagggagac tgcgataccc gtcccgaagg gagcctcccc cacgaagatc tcggtccaga agccatgacc gcctgcccta ccagaggagg taccgggagc gccgtgacag cgatacatac cggtgtgaag agcggagccc atcctttgga gaggactact atggaccttc acgttctcgt catcgtcggc gatcgcggga gagggggcca taccggaccc gcaagcatgc ccaccactgc cacaaacgcc gcaccaggtc ttgtagcagc gcctcctcga gaagccaaca gagcagtaag cgcagcagcc ggagtgtgga agatgacaag gagggtcacc tggtgtgccg gatcggcgat tggctccaag agcgatatga gattgtgggg aacctgggtg aaggcacctt tggcaaggtg gtggagtgct tggaccatgc cagagggaag tctcaggttg ccctgaagat catccgcaac gtgggcaagt accgggaggc tgcccggcta gaaatcaacg tgctcaaaaa aatcaaggag aaggacaaag aaaacaagtt cctgtgtgtc ttgatgtctg actggttcaa cttccacggt cacatgtgca tcgcctttga gctcctgggc aagaacacct ttgagttcct gaaggagaat aacttccagc cttaccccct accacatgtc cggcacatgg cctaccagct ctgccacgcc cttagatttc tgcatgagaa tcagctgacc catacagact tgaaaccaga gaacatcctg tttgtgaatt ctgagtttga aaccctctac aatgagcaca agagctgtga ggagaagtca gtgaagaaca ccagcatccg agtggctgac tttggcagtg ccacatttga ccatgagcac cacaccacca ttgtggccac ccgtcactat cgcccgcctg aggtgatcct tgagctgggc tgggcacagc cctgtgacgt ctggagcatt ggctgcattc tctttgagta ctaccggggc ttcacactct tccagaccca cgaaaaccga gagcacctgg tgatgatgga gaagatccta gggcccatcc catcacacat gatccaccgt accaggaagc agaaatattt ctacaaaggg ggcctagttt gggatgagaa cagctctgac ggccggtatg tgaaggagaa ctgcaaacct ctgaagagtt acatgctcca agactccctg gagcacgtgc agctgtttga cctgatgagg aggatgttag aatttgaccc tgcccagcgc atcacactgg ccgaggccct gctgcacccc ttctttgctg gcttgacccc tgaggagcgg tccttccaca ccagccgcaa cccaagcaga Protein function: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine- rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre- mRNA in endothelial cells. [The UniProt Consortium]