CLEC4E (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 660 Sequence: atgaattcat ctaaatcatc tgaaacacaa tgcacagaga gaggatgctt ctcttcccaa atgttcttat ggactgttgc tgggatcccc atcctatttc tcagtgcctg tttcatcacc agatgtgttg tgacatttcg catctttcaa acctgtgatg agaaaaagtt tcagctacct gagaatttca cagagctctc ctgctacaat tatggatcag gttcagtcaa gaattgttgt ccattgaact gggaatattt tcaatccagc tgctacttct tttctactga caccatttcc tgggcgttaa gtttaaagaa ctgctcagcc atgggggctc acctggtggt tatcaactca caggaggagc aggaattcct ttcctacaag aaacctaaaa tgagagagtt ttttattgga ctgtcagacc aggttgtcga gggtcagtgg caatgggtgg acggcacacc tttgacaaag tctctgagct tctgggatgt aggggagccc aacaacatag ctaccctgga ggactgtgcc accatgagag actcttcaaa cccaaggcaa aattggaatg atgtaacctg tttcctcaat tattttcgga tttgtgaaat ggtaggaata aatcctttga acaaaggaaa Protein function: A calcium-dependent lectin that acts as a pattern recognition receptor of the innate immune system. Recognizes damage-associated molecular patterns (DAMPs) of abnormal self and pathogen-associated molecular patterns (PAMPs) of bacteria and fungi (PubMed:18509109, PubMed:23602766). The PAMPs notably include mycobacterial trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid with potent adjuvant immunomodulatory functions (PubMed:23602766, PubMed:24101491). Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T- helper 17 cell subtypes. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia and mediates macrophage activation. Through recognition of DAMPs released upon nonhomeostatic cell death, enables immune sensing of damaged self and promotes inflammatory cell infiltration into the damaged tissue. [The UniProt Consortium]