CKAP5 (Vector pUC, Accession No. BC120869)

Length: 6099 Sequence: ATGGGAGATG ACAGTGAGTG GTTGAAACTG CCAGTTGATC AGAAATGTGA ACACAAGCTG TGGAAAGCAA GGTTAAGTGG GTATGAAGAG GCCCTGAAGA TCTTCCAGAA AATAAAGGAT GAAAAGAGCC CAGAGTGGTC CAAATTTTTA GGATTGATCA AAAAATTTGT CACTGATTCC AATGCAGTGG TTCAATTGAA AGGATTAGAA GCTGCACTTG TTTATGTTGA AAATGCCCAT GTAGCAGGAA AAACCACAGG AGAAGTTGTG TCAGGTGTTG TAAGTAAGGT GTTCAATCAA CCTAAAGCTA AAGCCAAGGA GCTGGGCATA GAGATCTGTC TTATGTACAT AGAGATTGAG AAAGGAGAGG CTGTTCAAGA AGAGCTCCTG AAAGGCTTGG ACAATAAGAA TCCCAAGATC ATAGTGGCCT GTATAGAGAC ACTGAGGAAA GCCTTAAGTG AATTTGGTTC CAAAATCATC TTGCTTAAGC CAATTATCAA AGTGTTGCCA AAACTCTTTG AGTCTCGAGA GAAGGCTGTT CGAGATGAAG CCAAACTAAT TGCTGTGGAG ATTTACAGAT GGATTCGGGA TGCTCTGAGA CCCCCATTAC AAAATATAAA CTCTGTTCAG TTGAAAGAAC TAGAAGAAGA ATGGGTCAAA CTGCCAACAA GTGCTCCTAG ACCTACTCGA TTTCTTCGTT CCCAACAAGA ACTAGAAGCT AAATTGGAAC AACAACAGTC TGCTGGTGGA GATGCTGAAG GAGGTGGTGA TGATGGTGAT GAGGTGCCAC AAATAGATGC TTATGAGCTT TTAGAAGCTG TAGAAATCCT TTCCAAACTT CCCAAAGACT TTTATGACAA AATTGAGGCA AAAAAATGGC AAGAGAGAAA AGAGGCCCTG GAGTCTGTAG AAGTACTAAT AAAAAACCCC AAACTGGAAG CTGGCGATTA TGCAGATTTA GTAAAAGCAT TAAAGAAGGT TGTTGGAAAG GACACCAATG TCATGTTGGT GGCTTTGGCA GCAAAATGTC TTACTGGCCT GGCTGTTGGG CTAAGGAAGA AATTTGGACA ATATGCAGGA CATGTTGTGC CAACCATCTT GGAGAAATTC AAAGAGAAGA AACCTCAAGT GGTACAAGCC CTGCAGGAGG CAATTGATGC AATCTTCCTT ACTACCACAC TACAGAACAT CAGTGAGGAT GTTTTAGCAG TAATGGATAA TAAAAATCCA ACCATCAAGC AGCAGACATC TCTTTTTATT GCAAGAAGTT TCCGCCACTG CACTGCTTCT ACCCTGCCAA AGAGCTTGCT AAAGCCCTTT TGTGCTGCAC TACTTAAGCA CATCAATGAT TCTGCTCCTG AAGTCAGAGA TGCCGCATTT GAAGCATTGG GTACTGCTTT GAAGGTGGTT GGCGAGAAAG CAGTAAACCC ATTCCTAGCT GATGTGGACA AACTCAAGCT TGATAAGATC AAAGAATGTT CAGAAAAGGT AGAACTGATA CATGGTAAGA AAGCTGGACT AGCTGCTGAT AAGAAGGAAT TCAAACCTCT GCCTGGAAGG ACTGCTGCTT CAGGGGCTGC AGGAGATAAG GACACAAAGG ACATTTCTGC ACCCAAACCA GGACCTCTAA AAAAGGCACC TGCTGCTAAG GCTGGTGGGC CACCAAAAAA GGGGAAACCA GCTGCACCAG GAGGCGCAGG GAATACTGGA ACCAAGAACA AGAAAGGACT GGAGACTAAA GAAATAGTGG AGCCTGAGCT CTCGATAGAA GTATGTGAAG AAAAAGCTTC AGCTGTTCTT CCCCCTACCT GTATACAGCT TCTTGACAGC AGTAACTGGA AAGAAAGGCT GGCTTGTATG GAAGAGTTCC AGAAGGCTGT TGAGCTAATG GACCGAACTG AAATGCCATG CCAGGCATTA GTGAGGATGC TAGCCAAGAA ACCTGGATGG AAAGAAACTA ATTTTCAGGT GATGCAAATG AAGCTTCATA TAGTTGCTTT GATTGCCCAG AAGGGAAATT TTTCCAAAAC GTCAGCTCAG GTTGTATTAG ATGGCCTTGT GGACAAGATT GGAGATGTGA AATGTGGGAA CAATGCAAAA GAAGCTATGA CAGCAATAGC CGAAGCCTGT ATGTTACCAT GGACTGCTGA ACAGGTTGTG TCAATGGCTT TCTCACAAAA GAATCCCAAA AATCAGTCAG AAACTCTGAA TTGGCTATCA AATGCCATAA AAGAATTTGG TTTTTCTGGG TTGAATGTCA AAGCTTTCAT TAGCAATGTG AAGACAGCTC TTGCTGCAAC AAACCCAGCT GTGAGGACTG CTGCCATAAC CCTGCTTGGC GTGATGTATC TGTATGTTGG TCCCTCTTTG CGAATGTTCT TTGAGGATGA GAAGCCTGCC CTCCTATCCC AGATAGATGC AGAATTTGAG AAGATGCAGG GACAAAGTCC ACCTGCTCCA ACCAGAGGAA TTTCCAAGCA TAGCACAAGT GGTACAGATG AAGGAGAAGA TGGAGATGAA CCAGATGACG GGAGCAATGA TGTCGTTGAT CTTTTGCCGA GGACGGAGAT CAGTGATAAA ATCACTTCAG AGTTGGTATC TAAGATTGGT GATAAGAATT GGAAGATTAG GAAAGAAGGC CTAGATGAAG TGGCAGGTAT TATTAATGAC GCAAAATTTA TCCAACCGAA TATAGGTGAA CTTCCAACTG CCTTGAAGGG TCGACTCAAT GATTCAAATA AAATCTTGGT ACAGCAAACG CTGAATATCC TGCAACAACT GGCAGTAGCC ATGGGCCCAA ATATTAAGCA ACATGTAAAA AATTTAGGCA TCCCTATCAT CACAGTCCTT GGAGACAGCA AGAACAATGT TCGAGCTGCT GCCCTAGCGA CTGTGAATGC TTGGGCAGAA CAGACTGGCA TGAAGGAATG GCTGGAAGGA GAAGATCTTT CTGAAGAGCT CAAAAAGGAA AATCCTTTCT TGAGGCAAGA GCTTCTGGGC TGGCTGGCTG AGAAACTACC TACTCTTCGT TCCACCCCTA CAGACCTTAT CCTTTGTGTT CCTCATCTCT ACTCCTGCCT AGAAGATCGA AATGGAGATG TGCGAAAGAA GGCCCAAGAT GCCTTGCCAT TCTTCATGAT GCATTTAGGA TATGAAAAAA TGGCCAAGGC TACTGGGAAA CTAAAGCCAA CTTCTAAAGA TCAGGTATTG GCCATGCTAG AGAAAGCCAA AGTTAACATG CCAGCCAAGC CTGCTCCACC CACTAAAGCA ACTTCTAAAC CAATGGGAGG GTCCGCTCCA GCCAAATTCC AGCCTGCATC AGCACCTGCT GAAGATTGTA TTTCCAGCAG TACAGAACCC AAACCTGATC CAAAAAAGGC CAAAGCTCCA GGATTATCCT CTAAAGCAAA GAGTGCACAA GGGAAGAAGA TGCCAAGCAA AACCAGCTTA AAGGAGGATG AAGACAAATC CGGGCCTATT TTTATTGTTG TTCCAAATGG AAAAGAGCAA AGGATGAAAG ATGAAAAAGG ATTGAAGGTG CTAAAGTGGA ATTTTACTAC CCCACGGGAT GAATACATTG AGCAACTAAA GACTCAAATG TCTAGCTGTG TGGCTAAATG GTTACAAGAT GAGATGTTTC ACTCAGACTT TCAGCATCAT AACAAAGCCC TTGCTGTTAT GGTTGATCAC TTGGAGAGTG AAAAAGAAGG AGTTATTGGG TGCCTGGATC TTATCTTAAA GTGGCTTACC CTGAGGTTTT TTGACACCAA TACAAGCGTC CTGATGAAAG CACTAGAATA TTTAAAATTG CTCTTCACCT TGCTAAGTGA AGAAGAATAT CATCTTACTG AGAATGAAGC ATCTTCCTTC ATCCCCTATC TTGTCGTCAA GGTTGGAGAA CCAAAGGATG TCATTCGTAA AGATGTTCGT GCCATCCTGA ACCGGATGTG CCTTGTCTAC CCAGCTAGCA AGATGTTTCC CTTTATCATG GAAGGAACCA AATCCAAAAA CTCTAAGCAG AGAGCAGAGT GCCTGGAAGA GCTGGGATGT CTGGTTGAGT CCTATGGCAT GAATGTTTGC CAACCAACCC CAGGAAAAGC CTTAAAGGAA ATAGCTGTTC ACATAGGAGA CCGTGACAAT GCTGTACGCA ATGCTGCACT CAACACCATT GTAACGGTGT ACAATGTACA TGGGGATCAG GTGTTCAAAC TGATTGGAAA TCTTTCTGAA AAGGATATGA GCATGCTCGA GGAGAGGATT AAGCGGTCAG CAAAGAGACC CTCTGCTGCA CCAATAAAAC AGGTGGAAGA GAAACCTCAG CGTGCACAGA ACATAAGCTC CAATGCCAAC ATGTTACGCA AGGGACCAGC TGAGGACATG TCTTCCAAAC TCAACCAAGC CCGAAGCATG AGTGGGCATC CTGAGGCAGC CCAGATGGTC CGCCGAGAAT TCCAGCTGGA TCTAGATGAG ATTGAGAATG ACAATGGTAC AGTCCGATGT GAAATGCCAG AACTTGTTCA GCACAAACTG GATGACATTT TTGAGCCAGT CCTTATTCCT GAACCCAAGA TCCGGGCTGT TTCTCCACAC TTCGATGACA TGCACAGTAA TACAGCATCC ACAATCAATT TCATTATCTC CCAAGTAGCC AGTGGTGACA TCAACACAAG TATCCAAGCT CTGACACAGA TCGATGAGGT CCTGAGACAG GAAGACAAAG CTGAAGCCAT GTCCGGCCAT ATTGATCAGT TTCTGATAGC CACTTTTATG CAGCTAAGAC TCATCTACAA CACACACATG GCAGATGAGA AATTGGAGAA GGACGAGATC ATCAAGTTGT ATAGCTGTAT CATTGGCAAC ATGATTTCGC TGTTTCAGAT AGAGAGCCTT GCCCGGGAGG CCTCCACTGG AGTACTAAAA GACCTAATGC ATGGCCTCAT CACCTTAATG CTGGATTCTC GGATTGAAGA TCTTGAGGAA GGACAACAGG TCATCCGCTC TGTGAACCTC TTGGTGGTGA AGGTTCTGGA GAAGTCAGAC CAGACCAACA TCCTGAGTGC CCTACTTGTT TTGCTCCAAG ACAGCCTGCT AGCAACAGCC AGTTCTCCCA AATTCTCAGA GCTTGTTATG AAGTGTCTCT GGAGAATGGT TCGACTGTTG CCTGATACCA TCAATAGCAT TAACCTAGAC AGAATTCTTC TGGATATCCA CATTTTCATG AAGGTCTTCC CCAAAGAGAA ACTGAAGCAA TGCAAAAGTG AATTTCCCAT AAGGACCCTA AAGACCCTGC TACACACCTT ATGCAAATTA AAAGGGCCCA AGATCCTGGA CCACCTAACG ATGATCGACA ACAAAAACGA GTCTGAGCTG GAGGCCCATC TCTGCCGGAT GATGAAGCAC AGTATGGACC AGACTGGGAG CAAGTCTGAT AAGGAAACAG AAAAGGGAGC ATCTCGAATA GATGAAAAAT CATCAAAGGC CAAAGTGAAT GATTTCTTAG CTGAGATTTT TAAGAAGATT GGCTCTAAAG AAAACACTAA AGAGGGACTA GCAGAGTTAT ATGAATATAA GAAGAAATAC TCAGATGCTG ACATTGAACC ATTTCTGAAA AATTCCTCAC AGTTCTTCCA GAGCTATGTC GAAAGAGGCC TTCGGGTGAT TGAGATGGAG AGGGAGGGCA AAGGTCGTAT TTCCACTTCA ACAGGCATCT CCCCTCAGAT GGAAGTCACA TGTGTGCCCA CGCCCACAAG CACAGTGTCC TCCATAGGTA ACACAAATGG GGAAGAAGTG GGGCCATCTG TCTACTTGGA AAGGCTAAAG ATCCTCCGAC AGCGATGTGG TCTGGACAAC ACAAAGCAAG ATGACCGACC TCCTTTGACC TCTTTGCTCT CCAAACCAGC AGTTCCTACT GTCGCCTCTT CCACAGACAT GCTCCACAGC AAACTCTCTC AGCTCCGGGA GTCACGGGAG CAGCACCAGC ATTCAGACCT GGATTCTAAC CAGACTCACT CTTCAGGAAC TGTGACCTCC TCCTCCTCCA CAGCTAACAT AGACGACTTG AAAAAAAGAC TGGAGAGAAT AAAGAGCAGT Protein function: Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch- TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). [The UniProt Consortium]