CHST4 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1113 Sequence: atggccatct tggctctatt cttccacatg tacagccaca acatcagctc cctgtctatg aaggcacagc ccgagcgcat gcacgtgctg gttctgtctt cctggcgctc tggctcttct tttgtggggc agctttttgg gcagcaccca gatgttttct acctgatgga gcccgcctgg cacgtgtgga tgaccttcaa gcagagcacc gcctggatgc tgcacatggc tgtgcgggat ctgatacggg ccgtcttctt gtgcgacatg agcgtctttg atgcctacat ggaacctggt ccccggagac agtccagcct ctttcagtgg gagaacagcc gggccctgtg ttctgcacct gcctgtgaca tcatcccaca agatgaaatc atcccccggg ctcactgcag gctcctgtgc agtcaacagc cctttgaggt ggtggagaag gcctgccgct cctacagcca cgtggtgctc aaggaggtgc gcttcttcaa cctgcagtcc ctctacccgc tgctgaaaga cccctccctc aacctgcata tcgtgcacct ggtccgggac ccccgggccg tgttccgttc ccgagaacgc acaaagggag atctcatgat tgacagtcgc attgtgatgg ggcagcatga gcaaaaactc aagaaggagg accaacccta ctatgtgatg caggtcatct gccaaagcca gctggagatc tacaagacca tccagtcctt gcccaaggcc ctgcaggaac gctacctgct tgtgcgctat gaggacctgg ctcgagcccc tgtggcccag acttcccgaa tgtatgaatt cgtgggattg gaattcttgc cccatcttca gacctgggtg cataacatca cccgaggcaa gggcatgggt gaccacgctt tccacacaaa tgccagggat gcccttaatg tctcccaggc ttggcgctgg tctttgccct atgaaaaggt ttctcgactt cagaaagcct gtggcgatgc catgaatttg ctgggctacc gccacgtcag atctgaacaa gaacagagaa acctgttgct ggatcttctg tctacctgga ctgtccctga gcaaatccac Protein function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within mucin-associated glycans that ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X on receptors SPN/CD43, GLYCAM1 and MADCAM1. Also involved in biosynthesis of SELL ligand recognized by MECA-79 antibody. Plays a central role in lymphocyte trafficking during chronic inflammation. Has a catalytic preference for core 2-branched mucin-type O-glycans. Can use GlcNAcbeta1-6[Galbeta1-3]GalNAc-pNP (core 2), GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharide structures as acceptors. Has also activity toward core 3 of GlcNAcbeta1-3GalNAc-pNP. Its substrate specificity may be influenced by its subcellular location. [The UniProt Consortium]