CHMP6 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 606 Sequence: atgggtaacc tgttcggccg caagaagcag agccgcgtca cggagcagga caaggccatc ctgcaactga agcagcagcg ggacaagctg aggcagtacc agaagaggat cgcccagcag ctggagcgcg agcgcgccct ggcccggcag ctgctgcggg acggcaggaa ggaacgggcc aagctgctgc tcaagaagaa gcgataccag gagcagctcc tggacaggac ggagaaccag atcagcagcc tggaggccat ggttcagagt attgagttca cccagatcga aatgaaagtg atggaggggc tgcagtttgg aaatgagtgt ctgaacaaga tgcaccaggt gatgtccatt gaagaggtgg agaggatcct ggacgagacg caggaggccg tggagtacca gcggcaaata gacgagctcc tggcaggaag cttcactcag gaggatgaag acgccatcct ggaggagctg agcgcaatca ctcaggaaca aatagagctg ccagaggttc cctccgagcc ccttcctgag aagatcccag aaaacgtccc tgtcaaggcc aggcccaggc aggcggagct ggtggcagct Protein function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes. [The UniProt Consortium]