CEP63 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1488 Sequence: atggaggctt tgttagaagg aatacaaaat cgagggcatg gtgggggatt tttgacatct tgtgaagcag aactacagga gctcatgaaa cagattgaca taatggtggc tcataaaaaa tctgaatggg aaggacgtac acatgctcta gaaacttgct tgaaaatccg tgaacaggaa cttaagagtc ttaggagtca gttggatgtg acacataagg aggttggaat gttgcatcag caggtagaag aacatgaaaa aatcaagcaa gagatgacca tggaatataa gcaggagttg aagaaactac atgaagaatt atgcatactg aagagaagct atgaaaagct tcagaaaaag caaatgaggg aattcagagg aaataccaaa aatcacaggg aagatcggtc tgaaattgag aggttaactg caaaaataga ggaattccgt cagaaatcgc tggactggga gaagcaacgc ttgatttatc agcaacaggt atcttcactg gaggcacaaa ggaaggctct ggctgaacaa tcagagataa ttcaggctca gcttgtcaat cggaaacaga aattagagtc tgtggaactt tctagccaat cagaaattca acacttaagc agtaaactgg agcgggctaa tgacactatc tgtgccaatg agttggaaat agagcgcctc accatgaggg tcaatgactt ggttggaacc agtatgactg tcctacagga gcagcagcaa aaagaagaaa aattgaggga atctgaaaaa ctattagagg ctctgcagga agaaaagaga gaattgaagg cagctcttca gtctcaagaa aatctcatac atgaggccag aatacaaaag gagaagttac aagaaaaagt aaaggcaact aacactcaac atgctgtaga agctataagt ttggaatctg tgagtgcaac gtgtaaacag ctgagccaag aactaatgga aaaatatgaa gaactgaaga ggatggaagc acataacaat gaatacaaag cagagattaa gaagttgaaa gaacagattt tacagggtga acaaagttac agttctgcac tagaaggaat gaagatggaa atctcccatc taactcagga gttacatcag cgagatatca ctattgcttc caccaaaggt tcttcctcag acatggaaaa gcgactcaga gcagagatgc aaaaggcaga agacaaagca gtagagcata aggagatttt ggatcagctg gagtcactca aattagaaaa tcgtcatctt tctgaaatgg tgatgaaatt ggaattgggt ttacatgagt gttccttgcc tgtatctccc cttggttcaa tagctaccag atttttggaa gaggaggaac tgaggtctca tcacattcta gagcgcttgg atgcccatat tgaagaacta aaaagagaga gtgaaaagac agtgagacaa ttcacagcct Protein function: Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication, the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152, however, this function has been questioned (PubMed:21983783, PubMed:26297806). Also recruits CDK1 to centrosomes (PubMed:21406398). Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes, this leads to the inactivation of spindle assembly and delay in mitotic progression (PubMed:21406398). [The UniProt Consortium]