CDK5RAP1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pU

Length: 1764 Sequence: atgcaccctt tacagtgtgt cctccaagtg cagaggtctc tggggtgggg accattggcc tctgtgtctt ggctgtcgct gaggatgtgc agggcacaca gcagtctctc tagtaccatg tgtcccagtc cagagaggca ggaggatgga gctcggaagg atttcagctc caggctggct gctggaccga cttttcaaca ttttttaaaa agtgcctcag ctcctcagga gaagctgtct tcagaagtgg aagacccacc tccctatctc atgatggatg aacttcttgg aaggcagaga aaagtctacc tcgagaccta tggctgccag atgaatgtga atgacacaga gatagcctgg tccatcttac agaagagtgg ctacctgcgg accagtaacc tccaagaggc agatgtgatt ctccttgtca cgtgctctat cagggagaag gctgagcaga ccatctggaa ccgtttacat cagcttaaag ccttgaagac aaggcggccc cgctcccggg ttcctctgag gattggaatt ctaggctgca tggctgagag gttgaaggag gagattctca acagagagaa aatggtagat attttggctg gtcctgatgc ctaccgggac cttccccggc tgctggctgt tgctgagtcg ggccagcaag ctgccaacgt gctgctctct ctggacgaga cctatgctga tgtcatgcca gtccagacaa gcgccagtgc cacgtctgcc tttgtgtcaa tcatgcgagg ctgtgacaac atgtgtagct actgcattgt tcctttcacc cggggcaggg agaggagtcg gcctattgcc tccattctag aggaagtgaa gaagctttct gagcaggggc tgaaagaagt gacacttctt ggtcagaatg ttaatagttt tcgggacaat tcggaggtcc agttcaacag tgcagtgcct accaatctca gtcgtggctt taccaccaac tataaaacca agcaaggagg acttcgtttt gctcatcttc tggatcaggt ctccagagta gatcctgaaa tgaggatccg ttttacctct ccccacccca aggattttcc tgatgaggtt ctgcagctga ttcatgagag agataacatc tgtaaacaga tccacctgcc agcccagagt ggaagcagcc gtgtgttgga ggccatgcgg aggggatatt caagagaagc ttatgtggag ttagttcacc atattagaga atctattcca ggtgtgagcc tcagcagcga tttcattgct ggcttttgtg gtgagacgga ggaagatcac gtccagacag tctctttgct ccgggaagtt cagtacaaca tgggcttcct ctttgcctac agcatgagac agaagacacg ggcatatcat aggctgaagg atgatgtccc ggaagaggta aaattaaggc gtttggagga actcatcact atcttccgag aagaagcaac aaaagccaat cagacctctg tgggctgtac ccagttggtg ctagtggaag ggctcagtaa acgctctgcc actgacctgt gtggcaggaa tgatggaaac cttaaggtga tcttccctga tgcagagatg gaggatgtca ataaccctgg gctcagggtc agagcccagc ctggggacta tgtgctggtg aagatcacct cagccagttc tcagacactt aggggacatg ttctctgcag gaccactctg agggactctt ctgcatattg Protein function: Methylthiotransferase that catalyzes the conversion of N6- (dimethylallyl)adenosine (i(6)A) to 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 (adjacent to the 3'-end of the anticodon) of four mitochondrial DNA-encoded tRNAs (Ser(UCN), Phe, Tyr and Trp) (PubMed:22422838, PubMed:25738458, PubMed:28981754). Essential for efficient and highly accurate protein translation by the ribosome (PubMed:22422838, PubMed:25738458, PubMed:28981754). Specifically inhibits CDK5 activation by CDK5R1 (PubMed:11882646). Essential for efficient mitochondrial protein synthesis and respiratory chain, shows pathological consequences in mitochondrial disease (PubMed:25738458). [The UniProt Consortium]