CDK5RAP1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pU

Length: 1533 Sequence: atgcaccctt tacagtgtgt cctccaagtg cagaggtctc tggggtgggg accattggcc tctgtgtctt ggctgtcgct gaggatgtgc agggcacaca gcagtctctc tagtaccatg tgtcccagtc cagagaggca ggaggatgga gctcggaagg atttcagctc caggctggct gctggaccga cttttcaaca ttttttaaaa agtgcctcag ctcctcagga gaagctgtct tcagaagtgg aagacccacc tccctatctc atgatggatg aacttcttgg aaggcagaga aaagtctacc tcgagaccta tggctgccag atgaatgtga atgacacaga gatagcctgg tccatcttac agaagagtgg ctacctgcgg accagtaacc tccaagaggc agatgtgatt ctccttgtca cgtgctctat cagggagaag gctgagcaga ccatctggaa ccgtttacat cagcttaaag ccttgaagac aaggcggccc cgctcccggg ttcctctgag gattggaatt ctaggctgca tggctgagag gttgaaggag gagattctca acagagagaa aatggtagat attttggctg gtcctgatgc ctaccgggac cttccccagc tgctggctgt tgctgagtcg ggccagcaag ctgccaacgt gctgctctct ctggacgaga cctatgctga tgtcatgcca gtccagacaa gcgccagtgc cacgtctgcc tttgtgtcaa tcatgcgagg ctgtgacaac atgtgtagct actgcattgt tcctttcacc cggggcaggg agaggagtcg gcctattgcc tccattctag aggaagtgaa gaagctttct gagcaggttc tgcagctgat tcatgagaga gataacatct gtaaacagat ccacctgcca gcccagagtg gaagcagccg tgtgttggag gccatgcgga ggggatattc aagagaagct tatgtggagt tagttcacca tattagagaa tctattccag gtgtgagcct cagcagcgat ttcattgctg gcttttgtgg tgagacggag gaagatcacg tccagacagt ctctttgctc cgggaagttc agtacaacat gggcttcctc tttgcctaca gcatgagaca gaagacacgg gcatatcata ggctgaagga tgatgtcccg gaagaggtaa aattaaggcg tttggaggaa ctcatcacta tcttccgaga agaagcaaca aaagccaatc agacctctgt gggctgtacc cagttggtgc tagtggaagg gctcagtaaa cgctctgcca ctgacctgtg tggcaggaat gatggaaacc ttaaggtgat cttccctgat gcagagatgg aggatgtcaa taaccctggg ctcagggtca gagcccagcc tggggactat gtgctggtga agatcacctc agccagttct cagacactta ggggacatgt tctctgcagg accactctga gggactcttc tgcatattgc Protein function: Methylthiotransferase that catalyzes the conversion of N6- (dimethylallyl)adenosine (i(6)A) to 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 (adjacent to the 3'-end of the anticodon) of four mitochondrial DNA-encoded tRNAs (Ser(UCN), Phe, Tyr and Trp) (PubMed:22422838, PubMed:25738458, PubMed:28981754). Essential for efficient and highly accurate protein translation by the ribosome (PubMed:22422838, PubMed:25738458, PubMed:28981754). Specifically inhibits CDK5 activation by CDK5R1 (PubMed:11882646). Essential for efficient mitochondrial protein synthesis and respiratory chain, shows pathological consequences in mitochondrial disease (PubMed:25738458). [The UniProt Consortium]