CCDC22 (Vector pUC, Accession No. BC000972)

Length: 1884 Sequence: atggaggagg cggaccgaat cctcatccat tcgctgcgcc aggccggcac ggcagttcct ccagatgtgc agaccttgcg cgccttcacc actgagctgg ttgtagaggc tgtggtccgc tgcctgcgtg tgatcaaccc tgcggtgggc tctggcctca gccctctgct gcctcttgcc atgtctgccc ggttccgcct ggccatgagc ctggctcagg cctgcatgga cctgggctat cccttggagc ttggctatca gaacttcctc taccccagtg agcctgacct ccgagacctg cttctcttct tggctgagcg tctgcccacc gatgcctctg aggatgcaga ccagcctgca ggtgactcag ctattctcct ccgggccatt gggagccaaa ttcgggacca gctggcactg ccttgggtcc cgccccacct tcgcactccc aagctgcagc acctccaggg ctcggccctc cagaagcctt tccatgccag caggctggtc gtgccagaat tgagttccag aggtgagcca cgggagttcc aggcgagtcc cctgctgctt ccagtcccta cccaggtgcc tcagcctgtt ggaagggtgg cctcgctcct cgaacaccat gccctgcagc tctgccagca gacgggccgg gaccggccag gggatgagga ctgggtccac cggacatccc gcctcccacc ccaggaggac acacgggctc agcggcagcg gctgcagaag caactgactg agcatctgcg ccaaagctgg ggcctgcttg gggcccccat acaagcccgg gacctgggag aactgctgca ggcctggggt gctggggcca agactggtgc tcctaagggc tcccgcttca cgcactcaga gaagttcacc ttccatctgg agccccaggc ccaggccact caggtgtcag atgtgccagc cacctcccgg cggcctgaac aggtcacgtg ggcagctcag gaacaggagc tcgagtccct tcgggagcag ctggaaggag tgaaccgcag cattgaggag gttgaggccg acatgaagac cctgggcgtc agctttgtgc aggcagagtc tgagtgccgg cacagcaagc tcagtacagc agagcgtgag caggccctgc gcctgaagag ccgcgcggtg gagctgctgc ccgatgggac tgccaacctt gccaagctgc agcttgtggt ggagaatagt gcccagcggg tcatccactt ggcgggtcag tgggagaagc accgggtccc actcctcgct gagtaccgcc acctccgaaa gctgcaggat tgcagagagc tggaatcttc tcgacggctg gcagagatcc aagaactgca ccagagtgtc cgggcggctg ctgaagaggc ccgcaggaag gaggaggtct ataagcagct gatgtcagag ctggagactc tgcccagaga tgtgtcccgg ctggcctaca cccagcgcat cctggagatc gtgggcaaca tccggaagca gaaggaagag atcaccaaga tcttgtctga tacgaaggag cttcagaagg aaatcaactc cctatctggg aagctggacc ggacgtttgc ggtgactgat gagcttgtgt tcaaggatgc caagaaggac gatgctgttc ggaaggccta taagtatcta gctgctctgc acgagaactg cagccagctc atccagacca tcgaggacac aggcaccatc atgcgggagg ttcgagacct cgaggagcag atcgagacag agctgggcaa gaagaccctc agcaacctgg agaagatccg ggaggactac cgagccctcc gccaggagaa cgctggcctc ctaggccggg tccgggaggc Protein function: Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation, the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10 (PubMed:23563313). Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1 (PubMed:28892079, PubMed:25355947). Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery, the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes (PubMed:25355947). [The UniProt Consortium]