CCDC115 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 399 Sequence: atgggcgcca agtcggtagg gcccctgcag tatgcttccc acatggagcc ccaggtctgc ctccacgcca gcgaggccca ggagggactc cagaagttca aggtggtgag agctggtgtc cacgccccag aggaggtggg gcctcgcgaa gcaggtctgc ggaggcgcaa gggccccact aagaccccag aaccggagtc ctctgaggcc cctcaggacc ccctgaactg gtttggaatc ctagttcctc acagtctacg tcaggctcaa gcaagcttcc gggatggcct gcagctggcc gcagacatag ccagcctcca gaaccgcatt gactggggtc gaagccagct ccggggactc caagagaaac tcaagcagct ggagcctggg Protein function: Accessory component of the proton-transporting vacuolar (V)- ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (PubMed:28296633). May be involved in Golgi homeostasis (PubMed:26833332). [The UniProt Consortium]