CBLC (Vector pUC, Accession No. BC028915)

Length: 1425 Sequence: atggctctgg cggtggcccc gtgggggcga cagtgggaag aggcccgcgc cctgggccgg gcagtcagga tgctgcagcg cctagaagag caatgcgtcg acccccggct gtccgtgagt cccccttcgc tgcgggacct gctgccccgc acagcgcagc tgcttcgaga ggtggcccat tctcggcggg cggccggcgg aggcggcccc gggggtcccg gcggctctgg ggactttcta ctcatctacc tggccaatct ggaggccaag agcaggcagg tggccgcgct gctgcctccc cggggccgaa ggagtgccaa cgacgagctc ttccgggcgg gctccagact caggcgacag ctggccaagc tggccatcat cttcagccac atgcacgcag agctgcacgc actcttcccc gggggaaagt actgtggaca catgtaccag ctcaccaagg cccccgccca caccttctgg agggaaagtt gcggagcccg gtgtgtgctg ccctgggctg agtttgagtc cctcctgggc acctgccacc ctgtggaacc aggctgcaca gccctggcct tgcgcaccac cattgacctc acctgcagcg ggcacgtgtc catcttcgag ttcgacgtct tcaccaggct ctttcagcca tggccaacac tcctcaagaa ctggcagctc ctggcagtca accacccagg ctacatggcc ttcctcacct atgatgaggt ccaagagcgt ctgcaggcct gcagggacaa gccaggcagt tacatcttcc ggcccagctg tactcgcctg gggcagtggg ccatcggcta tgtgagctca gatggcagca tcctgcagac catccctgcc aacaaacccc tgtcccaggt gctcctggag ggacagaagg acggcttcta cctctaccca gatggaaaga cccacaaccc agacctgact gagctcggcc aggcagaacc ccagcagcgc atccacgtgt cagaggagca gctgcagctc tactgggcca tggactccac atttgagctc tgcaagatct gtgctgagag caacaaggat gtgaagattg agccgtgcgg gcacctgctc tgcagctgct gcctggctgc ctggcagcac tcggacagcc agacctgccc cttctgccgc tgcgagatca agggctggga ggccgtgagt atctaccagt tccacggtca ggctactgct gaggacccag ggaacagcag tgaccaggaa ggcagggagt tggagctggg gcaggtgccc ctttcggctc ctccattgcc cccacggcca gatctgcccc ccaggaagcc cagaaatgcc cagccgaaag tgagactcct aaaggggaac tcccctccag ctgcgctggg accccaggac cctgccccgg Protein function: Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction, upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation, CD2AP converts it from an inhibitor to a promoter of RET degradation, the function limits the potency of GDNF on neuronal survival. [The UniProt Consortium]