CBFA2T2 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 792 Sequence: atgcatggat cgcctgtgga agtgaagata cagtccagat cctcacctcc caccatgcca cccctcccac caataaatcc tggaggaccg aggccagtgt ccttcactcc tactgcatta agcaatggca tcaaccattc tcctcctacc ctgaatggtg ccccatcacc gccacagaga ttcagcaatg gtcctgcctc ctccacatca tctgcactca caaatcagca attgccagcc acttgtggtg ctcgacaact cagcaagttg aaacgctttc ttaccactct gcaacagttt ggcaatgaca tctcccctga gattggggag aaggtgcgga ctcttgttct tgcactggtg aactcaacag tgacaattga ggaattccac tgtaagctcc aagaagccac aaactttccc cttcgtcctt ttgtgattcc atttctcaag gccaacctgc ccctgctgca gcgggaactg ctgcactgcg ctcgggcggc caagcagacc ccatcccagt acctggctca gcacgaacac cttctgctca acacaagcat tgcatcgcct gctgactcgt cagagttgct catggaggtg cacggaaatg ggaagaggcc cagtccagag agctgcataa tacatctaaa atctatggga gtagcttcca gacatgagta tttttcggga actcttcaga tgcctgcaca cccggtaaga aactctactc tagagaattt atgggtcgac tgttccagaa gcctcaggag tacagttctg ccttttcctt Protein function: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218). Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization- dependent manner. Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8,21). May thus be involved in the repression of AML1-dependent transcription and the induction of G- CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation. [The UniProt Consortium]