CBFA2T2 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 1845 Sequence: atggggtttc accatgttgg ccaggctcgt cttgaactcc tgacctcagg tgatctgcct gcattggcct cccaacgtgc tgggattaca gttggtcctg agaaaagggt gccagcgatg cctggatcgc ctgtggaagt gaagatacag tccagatcct cacctcccac catgccaccc ctcccaccaa taaatcctgg aggaccgagg ccagtgtcct tcactcctac tgcattaagc aatggcatca accattctcc tcctaccctg aatggtgccc catcaccgcc acagagattc agcaatggtc ctgcctcctc cacatcatct gcactcacaa atcagcaatt gccagccact tgtggtgctc gacaactcag caagttgaaa cgctttctta ccactctgca acagtttggc aatgacatct cccctgagat tggggagaag gtgcggactc ttgttcttgc actggtgaac tcaacagtga caattgagga attccactgt aagctccaag aagccacaaa ctttcccctt cgtccttttg tgattccatt tctcaaggcc aacctgcccc tgctgcagcg ggaactgctg cactgcgctc gggcggccaa gcagacccca tcccagtacc tggctcagca cgaacacctt ctgctcaaca caagcattgc atcgcctgct gactcgtcag agttgctcat ggaggtgcac ggaaatggga agaggcccag tccagagagg agagaagaga atagttttga tagagacaca attgctcctg agcctcctgc caagagagta tgtaccatca gccctgctcc tcggcacagt cctgctctca ctgtgcccct catgaatcct gggggccaat tccatcctac ccctccacct cttcagcatt acaccttaga ggatattgca acttctcacc tgtatcggga acccaacaag atgctagagc atcgagaagt tcgtgataga caccacagtc ttggtctaaa tggaggctat caagatgagt tggtagatca tcgtttgaca gaaagggaat gggctgatga atggaaacat cttgaccatg cgctgaattg cattatggaa atggtagaga aaacaaggcg ctctatggca gttctgcggc gctgtcagga atcagatcgt gaagaactca actactggaa aagacggtac aatgaaaaca cagagctgag gaaaacgggg accgagttgg tctccaggca gcacagccct gggagtgcag attctctcag caatgattct cagagagagt tcaacagcag gccaggtaca ggatacgtac ctgtggagtt ttggaaaaaa acagaagaag ctgtgaataa ggtgaaaatt caggccatgt cagaagtaca gaaggccgtc gctgaggcag agcagaaagc ctttgaagtg attgcaacag agagagcacg aatggagcaa accatagcgg atgtcaagcg gcaggccgca gaggatgctt tcctcgtcat caatgagcaa gaggagtcca cggagaactg ctggaactgt ggccgcaaag ccagcgagac atgcagtggc tgcaatatcg cgcgatactg tggctctttc tgccagcaca aggactggga gcggcaccac cgcctctgtg gtcagaacct gcatggccag agcccccacg gccagggccg gccgctgctt cctgtaggca ggggctcctc tgccaggtcc gccgactgca gcgtgcccag cccagccctc gacaagacct cggcaaccac atcgcgttcc tcaacacctg cttctgtgac agctatcgac accaacggac Protein function: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218). Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization- dependent manner. Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8,21). May thus be involved in the repression of AML1-dependent transcription and the induction of G- CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation. [The UniProt Consortium]