CARD14 (Vector pUC, Accession No. BC018142)

Length: 2223 Sequence: atgggggaac tgtgccgcag ggactccgca ctcacggcac tggacgagga gacactgtgg gagatgatgg agagccaccg ccacaggatc gtacgctgca tctgccccag ccgcctcacc ccctacctgc gccaggccaa ggtgctgtgc cagctggacg aggaggaggt gctgcacagc ccccggctca ccaacagcgc catgcgggcc gggcacttgc tggatttgct gaagactcga gggaagaacg gggccatcgc cttcctggag agcctgaagt tccacaaccc tgacgtctac accctggtca ccgggctgca gcctgatgtt gacttcagta actttagcgg tctcatggag acatccaagc tgaccgagtg cctggctggg gccatcggca gcctgcagga ggagctgaac caggaaaagg ggcagaagga ggtgctgctg cggcggtgcc agcagctgca ggagcacctg ggcctggccg agacccgtgc cgagggcctg caccagctgg aggctgacca cagccgcatg aagcgtgagg ttagcgcaca cttccatgag gtgctgaggc tgaaggacga gatgctcagc ctctcgctgc actatagcaa tgcgctgcag gaaaaggagc tggccgcctc acgctgccgc agcctgcagg aggagctgta tctactgaag caggagctgc agcgagccaa catggtttcc tcctgtgagc tggaattgca agagcagtcc ctgaggacag ccagcgacca ggagtccggg gatgaggagc tgaaccgcct gaaggaggag aatgagaaac tgcgctcgct gactttcagc ctggcggaga aggacattct ggagcagagc ctggacgagg cgcgggggag ccgacaggag ctggtggagc gcatccactc gctgcgggag cgggccgtgg ctgccgagag gcagcgagag cagtactggg aagagaagga acagaccctg ctgcagttcc agaagagtaa gatggcctgc caactctaca gggagaaggt gaatgcgctg caggcccagg tgtgcgagct gcagaaggag cgagaccagg cgtactccgc gagggacagt gctcagaggg agatttccca gagcctggtg gagaaggact ccctccgcag gcaggtgttc gagctgacgg accaggtctg cgagctgcgc acacagcttc gccagctgca ggcagagcct ccgggtgtgc tcaagcagga agccaggacc agggagccct gtccacggga gaagcagcgg ctggtgcgga tgcatgccat ctgccccaga gacgacagcg actgcagcct cgtcagctcc acagagtctc agctcttgtc ggacctgagt gccacgtcca gccgcgagct ggtggacagc ttccgctcca gcagccccgc gccccccagc cagcagtccc tgtacaagcg ggtggccgag gacttcgggg aagaaccctg gtctttcagc agctgcctgg agatcccgga gggagacccg ggagccctgc cgggagctaa ggcaggcgac ccacacctgg attatgagct cctagacacg gcagaccttc cgcagctgga aagcagcctg cagccagtct cccctggaag gcttgatgtc tcggagagcg gcgtcctcat gcggcggagg ccagcccgca ggatcctgag ccaggtcacc atgctggcgt tccaggggga tgcattgctg gagcagatca gcgtcatcgg cgggaacctc acgggcatct tcatccaccg ggtcaccccg ggctcggcgg cggaccagat ggccttgcgc ccgggcaccc agattgtgat ggttgattac gaagcctcag agcccttgtt caaggcagtc ctggaggaca cgaccctgga ggaggccgtg gggcttctca ggagggtgga cggcttctgc tgcctgtctg tgaaggtcaa cacggacggt tataagaggc tactccagga cctggaggcc aaagtggcga cctcggggga ctcattctac atccgggtca acctggccat ggagggcagg gccaaagggg agctgcaggt gcattgcaac gaggtcctgc acgtcaccga caccatgttc cagggctgcg gctgctggca tgcccaccgc gtgaactctt acaccatgaa ggatactgcc gcgcacggca ccatccccaa ctactccagg Protein function: Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases (PubMed:11278692, PubMed:21302310, PubMed:27113748, PubMed:27071417). May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. [The UniProt Consortium]