CALCOCO1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pU

Length: 2076 Sequence: atggaagaat caccactaag ccgggcacca tcccgtggtg gagtcaactt tctcaatgta gcccggacct acatccccaa caccaaggtg gaatgtcact acacccttcc cccaggcacc atgcccagtg ccagtgactg gattggcatc ttcaaggtgg aggctgcctg tgttcgggat taccacacat ttgtgtggtc ttccgtgcct gaaagtacaa ctgatggttc ccccattcac accagtgtcc agttccaagc cagctacctg cccaaaccag gagctcagct ctaccagttc cgatatgtga accgccaggg ccaggtgtgt gggcagagcc cccctttcca gttccgagag ccaaggccca tggatgaact ggtgaccctg gaggaggctg atgggggctc tgacatcctg ctggttgtcc ccaaggcaac tgtgttacag aaccagctcg atgagagcca gcaagaacgg aatgacctga tgcagctgaa gctacagctg gagggacagg tgacagagct gaggagccga gtgcaggagc tcgagagggc tctggcaact gccaggcagg agcacacgga gctgatggaa cagtacaagg ggatttcccg gtcccatggg gagatcacag aagagaggga catcctgagc cggcaacagg gagaccatgt ggcacgcatc ctggagctag aggatgacat ccagaccatc agtgagaaag tgctgacgaa ggaagtggag ctggacaggc ttagagacac agtgaaggcc ctgactcggg aacaagagaa gctccttggg caactgaaag aagtacaagc agacaaggag caaagtgagg ctgagctcca agtggcacaa caggagaacc atcacttaaa tttggacctg aaggaggcga agagctggca agaggagcag agtgctcagg ctcagcgact gaaagacaag gtggcccaga tgaaggacac cctaggccag gcccagcagc gggtggccga gctggagccc ttgaaggagc agcttcgagg ggcccaggag cttgcagcct caagccagca gaaagccacc cttcttgggg aggagttggc cagtgcagca gcagccaggg accgcaccat agccgaacta caccgcagcc gcctggaagt ggctgaagtt aacggcaggc tggctgagct cggtttgcac ttgaaggaag aaaaatgcca atggagcaag gagcgggcag ggctgctgca gagtgtggag gcagagaagg acaagatcct gaagctgagt gcagagatac ttcgattgga gaaggcagtt caggaggaga ggacccaaaa ccaagtgttc aagactgagc tggcccggga gaaggattct agcctggtac agttgtcaga aagtaagcgg gagctgacag agctgcggtc agccctgcgt gtgctccaga aggaaaagga gcagttacag gaggagaaac aggaattgct agagtacatg agaaagctag aggcccgcct ggagaaggtg gcagatgaga agtggaatga ggatgccacc acagaggatg aggaggccgc tgtggggctg agctgcccgg cagctctgac agactcagag gacgagtccc cagaagacat gaggctccca ccctatggcc tttgtgagcg tggagaccca ggctcctctc ctgctgggcc tcgagaggct tctccccttg ttgtcatcag ccagccggct cccatttctc ctcacctctc tgggccagct gaggacagta gctctgactc ggaggctgaa gatgagaagt cagtcctgat ggcagctgtg cagagtgggg gtgaggaggc caacttactg cttcctgaac tgggcagtgc cttctatgac atggccagtg gctttacagt gggtaccctg tcagaaacca gcactggggg ccctgccacc cccacatgga aggagtgtcc tatctgtaag gagcgctttc ctgctgagag tgacaaggat gccctggagg accacatgga tggacacttc tttttcagca cccaggaccc cttcaccttt Protein function: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N- terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER- activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions. In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). [The UniProt Consortium]