C3orf37 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 1065 Sequence: atgtgtgggc gaacatcctg tcacttacct agagatgttc tcacgagagc ttgcgcctac caggatcggc ggggccagca gcggctcccg gagtggaggg accctgataa gtactgcccc tcttacaaca agagtcctca atccaacagc ccagtgcttc tgtctcgact gcactttgag aaggatgcag actcatctga gcgtatcatt gctcccatgc gctggggctt ggtcccttct tggttcaaag aaagtgatcc ttccaagctg cagttcaata ctaccaactg tcgtagtgat accgtaatgg agaaacggtc atttaaggtg cctctgggaa agggaagacg ctgtgtcgtt ttagcagatg gattctatga gtggcagcga tgtcagggaa caaaccagag gcagccatac ttcatctatt ttcctcaaat caagacagag aagtcaggta gcattggtgc tgcagatagt cctgagaact gggagaaagt ctgggacaac tggaggctgc tgacaatggc cgggatcttt gactgctggg agcccccaga gggaggagat gtcctgtatt cctataccat catcacagtg gattcctgca aaggcttgag tgacatccac cacaggatgc ctgccatatt agatggagag gaggcagttt ctaaatggct tgactttggt gaagtctcaa ctcaggaagc tctgaaatta atccacccaa cagagaacat caccttccat gcagtctctt ctgtggtgaa caactcgcga aacaacactc ctgagtgtct ggctcctgtc gacttggtgg tcaaaaagga gctcagggca agtggcagta gccagaggat gttgcagtgg ttggccacaa agtcacccaa aaaggaagac tcaaaaacac ctcaaaagga agagtcagat gttccccagt ggtccagtca gttcctgcag aagagtccac tccccaccaa gagaggcact gcaggactcc tagagcaatg gctgaagcgg gagaaggagg aggaacctgt ggccaagcgt ccttacagcc Protein function: Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites (PubMed:30554877, PubMed:31235915, PubMed:31235913). Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue (PubMed:30554877, PubMed:31235913). The HMCES DNA-protein cross-link is then degraded by the proteasome (PubMed:30554877). Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks (PubMed:30554877). Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction (PubMed:31235915, PubMed:31806351). Also involved in class switch recombination (CSR) in B-cells independently of the formation of a DNA- protein cross-link: acts by binding and protecting ssDNA overhangs to promote DNA double-strand break repair through the microhomology- mediated alternative-end-joining (Alt-EJ) pathway. Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine. [The UniProt Consortium]