C1orf135 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pU

Length: 1074 Sequence: atgaggcgga caggccccga ggaggaggcc tgcggcgtgt ggctggacgc ggcggcgctg aagaggcgga aagtgcagac acatttaatc aaaccaggca ccaaaatgct aacactcctt cctggagaaa gaaaggctaa tatttatttt actcaaagaa gagctccatc tacaggcatt caccagagaa gcattgcttc cttcttcacc ttgcagccag gaaagacaaa tggcagtgac cagaagagtg tttcatctca tacagaaagt cagatcaaca aagagtccaa gaaaaatgcg acccagctag accatttgat cccaggctta gcacacgatt gcatggcatc ccctttagcc acttcaacca ctgcagacat ccaggaagct ggactctctc ctcagtccct ccagacttct ggccaccaca gaatgaaaac cccattttca actgagctat ctttgctcca gcctgatact ccagactgtg ctggagatag tcatacccca ctggcttttt ccttcaccga ggacttggaa agttcttgtt tgctagaccg aaaggaagaa aaaggggatt ctgccaggaa atgggaatgg cttcatgagt ctaagaagaa ctatcagagt atggagaaac acaccaaact acctggggac aaatgctgtc agcccttagg caagactaaa ttggaaagaa aggtgtctgc caaagaaaac aggcaggccc ctgtcctcct tcaaacatac agggaatcct ggaatggaga aaacatagaa tcagtgaaac aaagccgtag tccagtttct gtgttttcct gggacaatga aaagaatgac aaggactcct ggagtcaact tttcactgaa gattctcaag gccagcgggt cattgcccac aacactagag ctccttttca agatgtaacc aataactgga attgggactt agggccgttt cctaacagtc cttgggctca gtgccaggag gatgggccaa ctcaaaatct gaagcctgat ttgctcttta cccaggactc tgaaggtaat caagttatca gacaccaatt Protein function: DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination (PubMed:29042561). Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair (PubMed:29042561). Inhibits non- homologous end joining (NHEJ) (PubMed:29042561). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle (PubMed:20596670). [The UniProt Consortium]