C18orf1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 867 Sequence: atgccggaag ctggttttca ggccacaaat gctttcacag agtgcaaatt cacctgcacc agtggtaaat gcttgtatct tggttcgctg gtctgtaacc aacagaacga ctgtggggac aacagtgacg aagagaactg tctcctggtg accgagcacc cgcctccggg catcttcaac tcggagctgg agttcgccca aatcatcatc atcgtcgtgg tggtcacggt gatggtggtg gtcatcgtct gcctgctgaa ccactacaaa gtctccacgc ggtccttcat caaccgcccg aaccagagcc ggaggcggga ggacgggctg ccgcagatca tgcatgcccc gcggtccagg gacaggttca cagcgccgtc cttcatccag agggatcgct tcagccgctt ccagcccacc tacccctatg tgcagcacga gattgatctt cctcccacca tctccctgtc cgacggtgaa gagccacctc cttaccaggg gccctgcacc ctgcagctcc gggaccctga acagcagatg gaactcaacc gagagtccgt gagggcccca cccaaccgaa ccatatttga cagtgattta atagacattg ctatgtatag cgggggtcca tgcccaccca gcagcaactc gggcatcagt gcaagcacct gcagcagtaa cgggaggatg gaggggccac cccccacata cagcgaggtg atgggccacc acccaggcgc ctctttcctc catcaccagc gcagcaacgc acacaggggc agcagactgc agtttcagca gaacaatgca gagagcacaa tagtacccat caaaggcaaa gataggaagc ctgggaacct Protein function: Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal. [The UniProt Consortium]