C18orf1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 690 Sequence: atggtggtgg tcatcgtctg cctgctgaac cactacaaag tctccacgcg gtccttcatc aaccgcccga accagagccg gaggcgggag gacgggctgc cgcaggaagg gtgcctgtgg ccttcagaca gcgccgcacc gcagctgggc gcctcggaga tcatgcatgc cacgcggtcc agggacaggt tcacagcgcc gtccttcatc cagagggatc gcttcagccg cttccagccc acctacccct atgtgcagca cgagattgat cttcctccca ccatctccct gtcggacggt gaagagccgc ctccttacca ggggccatgc accctgcagc tccgggacac tgaacagcag atggaactca accgagagtc cgtgagggcc ccacccaacc gaaccatatt tgacagtgat ttaatagaca ttgctatgta tagcgggggt ccatgcccac ccagcagcaa ctcgggcatc agtgcaagca cctgcagcag taacgggagg atggaggggc caccccccac atacagcgag gtgatgggcc accacccagg cgcctctttc ctccatcacc agcgcagcaa cgcacacagg ggcagcagac tgcagtttca gcagaacaat gcagagagca caatagtacc aatcaaaggc aaagatagga agcctgggaa Protein function: Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal. [The UniProt Consortium]