BBS9 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 933 Sequence: atgggatacc taaggatctt tagcccccat cctgcaaaaa caggagatgg agctcaagcc gaagatttgc ttctagaagt ggatctacga gatccagtac ttcaagtgga agtaggaaag tttgtttcag gtaccgaaat gctacatttg gctgtgttac attctagaaa actttgtgtc tactctgtct caggaacctt gggtaatgtg gaacatggga accaatgtca gatgaaattg atgtatgaac ataatcttca gagaacagcc tgcaatatga cctatggatc atttggtggt gtaaaaggtc gagatttaat ttgcatccag tctatggatg ggatgctgat ggtatttgag caggagagct atgcttttgg aagatttctc cctggctttc ttctgcctgg tcctcttgcc tacagttccc gtacagattc cttccttact gtctcttcct gccaacaagt ggaaagttat aagtaccagg tacttgcttt tgcaacagat gcagataaaa ggcaggagac tgaacagcaa aaacttggtt ctggaaaaag actagttgtg gattggactc taaatattgg agagcaagcc cttgacatat gtattgtctc tttcaatcag tcggcatcct ctgtttttgt tcttggtgag agaaactttt tttgccttaa ggataatgga caaattcgat tcatgaagaa gcttgattgg agcccaagtt gttttctgcc atattgctca gtttctgaag gaacaataaa tactttgatt ggaaatcata ataacatgct gcatatttat caagatgtga cactgaagtg ggccacccaa cttccccaca ttcctgtagc agtaagagtg ggctgtttgc aattttcttt atggaagcat ttgttgcctc gatcttccac tttagaaaaa Protein function: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for proper BBSome complex assembly and its ciliary localization. [The UniProt Consortium]