BBS9 (Vector pUC, Accession No. BC103831)

Length: 2664 Sequence: ATGTCTTTAT TTAAAGCCCG TGATTGGTGG TCTACTATTC TGGGAGATAA AGAAGAATTT GATCAAGGCT GTTTGTGTCT GGCTAATGTT GACAATAGTG GAAATGGACA AGATAAAATA ATTGTGGGTA GCTTTATGGG ATACCTAAGG ATCTTTAGCC CCCATCCTGC AAAAACAGGA GATGGAGCTC AAGCCGAAGA TTTGCTTCTA GAAGTGGATC TACGAGATCC AGTACTTCAA GTGGAAGTAG GAAAGTTTGT TTCAGGTACC GAAATGCTAC ATTTGGCTGT GTTACATTCT AGAAAACTTT GTGTCTACTC TGTCTCAGGA ACCTTGGGTA ATGTGGAACA TGGGAACCAA TGTCAGATGA AATTGATGTA TGAACATAAT CTTCAGAGAA CAGCCTGCAA TATGACCTAT GGATCATTTG GTGGTGTAAA AGGTCGAGAT TTAATTTGCA TCCAGTCTAT GGATGGGATG CTGATGGTAT TTGAGCAGGA GAGCTATGCT TTTGGAAGAT TTCTCCCTGG CTTTCTTCTG CCTGGTCCTC TTGCCTACAG TTCCCGTACA GATTCCTTCC TTACTGTCTC TTCCTGCCAA CAAGTGGAAA GTTATAAGTA CCAGGTACTT GCTTTTGCAA CAGATGCAGA TAAAAGGCAG GAGACTGAAC AGCAAAAACT TGGTTCTGGA AAAAGACTAG TTGTGGATTG GACTCTAAAT ATTGGAGAGC AAGCCCTTGA CATATGTATT GTCTCTTTCA ATCAGTCGGC ATCCTCTGTT TTTGTTCTTG GTGAGAGAAA CTTTTTTTGC CTTAAGGATA ATGGACAAAT TCGATTCATG AAGAAGCTTG ATTGGAGCCC AAGTTGTTTT CTGCCATATT GCTCAGTTTC TGAAGGAACA ATAAATACTT TGATTGGAAA TCATAATAAC ATGCTGCATA TTTATCAAGA TGTGACACTG AAGTGGGCCA CCCAACTTCC CCACATTCCT GTAGCAGTAA GAGTGGGCTG TTTGCATGAT TTAAAGGGAG TGATAGTCAC TCTGAGTGAT GATGGTCACT TGCAGTGTTC ATACCTGGGG ACAGATCCTT CTCTGTTCCA AGCTCCAAAC GTTCAATCTC GAGAACTAAA CTATGATGAA CTTGATGTAG AAATGAAAGA ACTTCAGAAA ATCATCAAAG ATGTTAACAA ATCACAAGGT GTTTGGCCCA TGACTGAGAG AGAAGATGAC TTGAACGTTT CTGTCGTGGT TTCTCCTAAC TTTGATTCAG TTTCTCAAGC GACCGATGTT GAGGTGGGAA CTGACCTTGT CCCTTCTGTC ACGGTGAAGG TCACACTGCA GAACAGAGTG ATATTGCAAA AAGCCAAATT ATCAGTCTAC GTGCAACCAC CATTAGAATT GACTTGTGAT CAGTTCACCT TTGAATTTAT GACACCAGAT TTGACTAGAA CAGTAAGCTT TTCTGTTTAT CTGAAAAGAA GTTATACACC ATCAGAATTG GAAGGAAATG CTGTTGTTTC TTATTCCAGA CCAACAGATC GAAATCCTGA TGGCATTCCG CGAGTTATCC AATGTAAATT TAGACTTCCC CTAAAGTTAA TTTGCCTACC AGGTCAGCCT TCAAAAACTG CAAGCCACAA AATTACTATT GATACCAACA AATCTCCAGT CAGTCTTCTT AGTCTCTTCC CAGGTTTTGC CAGTCAGTCA GATGATGATC AGGTGAATGT AATGGGTTTT CACTTCTTAG GAGGTGCTCG AATTACTGTT CTTGCTTCCA AAACTTCTCA ACGATATCGC ATTCAGAGTG AACAATTTGA AGATCTTTGG CTCATAACCA ATGAGCTTAT TCTTCGCCTT CAAGAATATT TTGAAAAACA GGGAGTCAAA GATTTTGCAT GTTCTTTTTC GGGATCTATA CCCCTTCAAG AATATTTTGA GTTGATTGAT CATCATTTTG AGCTACGGAT AAATGGTGAA AAATTAGAAG AACTCTTATC TGAGAGAGCT GTACAATTTC GGGCCATTCA ACGCCGGCTA CTAGCAAGAT TCAAAGATAA AACTCCTGCC CCTCTTCAAC ACCTGGACAC CTTGTTAGAT GGAACCTACA AGCAGGTAAT TGCTCTAGCA GATGCAGTGG AGGAAAACCA AGGCAATCTG TTCCAGTCAT TCACCAGGCT GAAGAGTGCC ACCCATTTGG TGATTCTGCT GATCGCGCTG TGGCAGAAGC TTAGTGCTGA CCAGGTTGCT ATTCTGGAAG CGGCATTTCT GCCGCTACAA GAAGACACTC AAGAATTGGG CTGGGAAGAA ACGGTGGATG CCGCCATTTC CCACCTGTTG AAGACTTGCC TGTCGAAGAG TTCTAAGGAG CAGGCTTTGA ACCTCAACAG CCAGCTGAAC ATACCCAAAG ACACAAGCCA ACTGAAGAAA CATATCACCT TGCTCTGCGA TAGATTATCC AAAGGTGGCC GTCTCTGCCT AAGTACCGAT GCAGCAGCCC CACAGACCAT GGTCATGCCA GGTGGTTGTA CTACAATCCC AGAGTCAGAC CTAGAAGAAA GATCAGTAGA ACAAGACTCT ACAGAACTGT TTACCAACCA CAGACATCTC ACTGCAGAGA CACCCAGGCC TGAAGTTTCA CCCCTCCAAG GAGTCTCGGA Protein function: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for proper BBSome complex assembly and its ciliary localization. [The UniProt Consortium]