BBS7 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 2019 Sequence: atggatctga ttttaaaccg aatggattat ctgcaggtgg gagtaacatc tcagaagact atgaagctaa ttcctgcctc aagacacaga gctacacaaa aggtggttat tggagatcat gatggggtag ttatgtgctt tggcatgaag aaaggagaag cagcagcagt gttcaagact ttacccgggc cgaagattgc aaggctggaa ctgggagggg ttatcaacac acctcaggag aaaattttta ttgctgcagc atctgagatt agaggcttca caaaaagagg aaaacagttc ctctcctttg aaacaaacct cactgaaagc attaaagcta tgcacatatc tggctcagac ctctttctca gtgcaagtta catctataac cattattgtg actgcaaaga ccaacattat tacctttctg gggataaaat caatgatgtg atctgccttc cagtggaaag attatctcgt atcacacctg tattggcctg ccaggacaga gtgctcagag ttttacaggg atctgatgtg atgtatgcag ttgaagttcc tggaccccct actgtcttag cactacacaa tggaaatggc ggtgactctg gagaagacct tttgtttggg acatcagacg gaaaacttgc gcttatacag attactacat ccaaaccagt acgcaagtgg gaaattcaaa atgagaaaaa gagaggaggt attttgtgta ttgacagctt tgacattgtg ggtgatgggg ttaaagattt acttgttggg agagatgacg gaatggtgga agtgtatagt tttgataatg caaatgaacc tgttctacga tttgatcaga tgttgtctga aagcgtcaca tctatccagg gtggttgtgt aggaaaagac agctatgatg aaatcgtggt gtccacatat tcaggctggg ttacaggtct gacaacagag cccattcata aggaaagtgg accaggagaa gaactaaaaa ttaatcagga gatgcagaat aaaatttctt ccttacggaa tgagttggaa catttgcagt ataaggtatt gcaggaaaga gagaattatc aacagtcttc tcaatcaagc aaagcaaaat cagcagtacc ttcctttggt ataaatgata aatttacact aaataaagat gatgccagtt acagccttat cttagaggta cagactgcaa tagataatgt cttaatacag agtgatgttc caatagattt acttgatgtg gataaaaatt ctgctgttgt tagctttagc agctgtgatt ctgagtcaaa cgacaacttc cttcttgcca cttatcggtg ccaggcagat actacaaggc tggaactcaa gattcgctca attgaaggcc agtatggcac actacaagca tatgtgactc caagaattca acccaaaacc tgtcaggtcc gccagtacca catcaaacct ctttcactcc atcaaagaac tcactttatt gatcatgaca gacccatgaa tacactgacc ctaacaggcc agttcagttt tgctgaagtt cactcctggg tggttttttg tctgcctgaa gttccagaaa aacctccagc aggagaatgt gtgacatttt actttcagaa cacctttcta gatacacaac ttgaaagtac ctacagaaaa ggagagggag tttttaaatc tgacaacatt tctactatct ccatcctaaa agatgtgctt tctaaagaag ctacaaaaag gaaaattaac ctcaacatat catacgagat aaatgaagta tcagtcaaac acactttaaa gctaatccac ccaaagctgg agtaccagtt gcttttggct aagaaagtgc agttaattga tgctttaaaa gaattacaga ttcatgaggg aaatacgaac tttctgatac cagaatatca ctgtattcta gaagaggcag atcacctaca ggaagaatac aaaaagcaac ctgcacatct tgaaagactc Protein function: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. [The UniProt Consortium]