BBS4 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 1560 Sequence: atggctgagg agagagtcgc gacgagaact caatttcctg tatctactga gtctcaaaaa ccccggcaga aaaaagctcc agagtttcct attttggaga agcagaactg gttgattcat cttcattata tccggaaaga ttatgaagcc tgcaaggctg ttatcaaaga acagcttcaa gagactcagg gattgtgtga atatgctatc tatgtccaag cattgatatt tcgcctagaa ggaaatatcc aagaatccct agaactcttc cagacatgtg cagttcttag tcctcagagt gctgataacc tcaagcaggt ggccagatct ttatttcttt tgggaaaaca taaagctgcc attgaagtat ataatgaagc agctaaactc aaccagaaag attgggagat cagccataac ctaggagttt gctacatata cctgaagcag ttcaacaagg cacaagacca gttgcacaat gccctgaatc ttaataggca cgatctgact tatataatgc tggggaagat ccacttgctg gagggagact tggacaaggc cattgaagtc tacaagaaag cagtggagtt ctcaccagaa aatacagagc ttcttacaac tttaggatta ctctacttac agctcggcat ttaccagaag gcatttgaac atcttggcaa tgcactgact tatgacccta ccaactacaa ggccatcttg gcagcaggca gcatgatgca gacccacggg gactttgatg ttgccctcac caaatacaga gttgtggctt gtgctgttcc agaaagtcct ccactctgga ataacattgg aatgtgtttc tttggcaaga agaaatatgt ggcggccatc agctgcctga aacgagccaa ctacttggca cccttcgatt ggaagattct gtataatttg ggccttgtcc atttgaccat gcagcagtat gcatcagctt ttcattttct cagtgcggcc atcaacttcc agccaaagat gggggagctc tacatgctct tggcagtggc tctgaccaat ctggaagata cagaaaatgc caagagagcc tacgcagaag cagtccacct ggataagtgt aaccctttag taaacctgaa ctatgctgtg ctgctgtaca accagggcga gaagaagaac gccctggtcc aatatcagga gatggagaag aaagtcagcc tactcaagga caatagctct ctggaatttg actctgagat ggtggagatg gctcagaagt tgggagctgc tctccaggtt ggggaggcac tggtctggac caaaccagtt aaagatccca aatcaaagca ccagaccact tcaaccagca aacctgccag tttccagcag cctctgggct ctaatcaagc tctaggacag gcaatgtctt cagcagctgc atacaggacg ctcccctcag gtgctggagg aacatcccag ttcacaaagc ccccatctct tcctctggag ccagagcctg cggtggaatc aagtccaact gaaacatcag aacaaataag Protein function: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome. [The UniProt Consortium]