ATXN7L3 (Vector pENTR223.1, Accession No. BC113595)

Length: 1044 Sequence: atgaaaatgg aggaaatgtc tttgtctggc ctggataaca gcaaactaga ggccatcgct caggagatat acgcggacct ggtcgaggat tcttgtttgg gattctgctt tgaggtacac cgggctgtca agtgtggcta cttcttcttg gacgacacgg accctgatag catgaaggat tttgagatcg tggaccagcc gggcttggac atctttggac aggttttcaa ccagtggaag agcaaggagt gtgtttgccc caattgcagt cgcagcattg ccgcctcccg ctttgctccc catctggaga agtgcctggg aatgggtcgg aacagcagcc gaatcgccaa ccgccggatt gccaatagca acaatatgaa taagtctgag agtgaccaag aagataatga tgacatcaat gacaacgact ggtcctatgg ctcggagaag aaagccaaga agagaaagtc agacaagaac cccaattccc ctcgaagatc caagtcatta aaacacaaaa atggggaact tagcaattcg gatcctttta agtataacaa ttcaactggg atcagctatg agaccctggg gccggaggag cttcgcagcc tgctaaccac gcaatgtggg gtgatttctg aacacaccaa gaagatgtgc acaaggtccc tgcgctgccc acagcacaca gatgagcaga ggcgaaccgt acggatttat tttctcgggc cctcggctgt ccttccagag gtcgagagct ccctggataa tgacagcttt gacatgactg acagccaggc cctgatcagc cggcttcagt gggacggctc ctctgacctc tcaccctctg attcaggctc ctccaagacg agtgaaaatc agggatgggg tctaggtacc aacagctctg agtcacggaa aaccaagaaa aagaaatccc atctgagcct ggtagggact gcctccggcc taggttccaa caagaagaag aagccaaagc caccggcacc cccgacgccc agcatctatg atgacatcaa Protein function: Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B (PubMed:18206972, PubMed:21746879). The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex (PubMed:18206972). Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B (PubMed:27601583). [The UniProt Consortium]