ATP6V0A2 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pU

Length: 2571 Sequence: atggggtccc tgttccggag cgagaccatg tgcctggcgc agctcttcct gcagtcgggc acggcctacg agtgcctcag cgccctgggc gagaaaggcc tggtccagtt ccgagacctc aaccagaacg taagttcttt ccaaagaaaa tttgttggtg aggtgaagag gtgtgaagag ctagagcgaa tattggtgta tttggtacag gaaattaata gagctgatat tccccttcct gaaggagagg ccagccctcc tgcgccaccc ctgaaacagg ttctagaaat gcaggagcag ttgcagaagc tcgaggttga actgagagaa gtcactaaga acaaggagaa actgaggaaa aacttgctgg aactgataga gtacactcac atgctgagag tgacaaagac ctttgtgaaa cgcaacgttg agtttgaacc cacttatgaa gaattccctt ccttagagag cgattctttg ttggattaca gctgtatgca gaggctggga gcaaaactgg gatttgtgtc tggcctaatt aaccaaggaa aagtggaagc atttgaaaaa atgttgtgga gagtctgcaa agggtacacc atcgtgtcct atgcagaact ggatgaatcc cttgaagacc ctgaaacagg ggaagtcata aaatggtatg tctttttaat atccttttgg ggagagcaga ttggccacaa ggttaagaag atatgtgatt gctaccactg ccacgtgtac ccctatccaa acacagccga ggagcggagg gagatccagg aggggctgaa cacccgcatc caggatctct acactgtact gcacaaaacc gaggactatt tgaggcaagt gctatgtaaa gccgccgagt ctgtctacag ccgtgtgatc caggtgaaga aaatgaaggc catctatcac atgctgaaca tgtgcagctt tgacgtgacc aacaagtgcc tcattgctga ggtctggtgt cccgaggcgg atctgcagga cctgcgccgg gcactggagg agggctcgag agagagtggt gctacaatcc cctcattcat gaatataatc cccacaaaag aaacaccccc cactcggatc cgcaccaaca aattcaccga gggatttcag aacatcgtgg atgcttatgg agtcggaagc tacagagaag tcaatccagc tctctttacc atcatcacct tcccgttttt atttgctgtg atgtttggag acttcggaca tggctttgtg atgtttttat ttgccctctt gttggtgtta aatgaaaatc atcccagact aaatcagtca caagagatca tgaggatgtt ttttaatggc cggtacatcc tcctgctgat ggggctgttc tcagtgtaca ctggcctcat ctacaacgac tgcttttcaa agtcagtcaa cctgttcggc tctgggtgga acgtgtcggc catgtacagc tccagccacc cacccgcaga gcataagaag atggtgcttt ggaacgacag cgtcgttaga cacaacagca ttttgcagct ggatccaagc attcctggag tgttccgagg cccttatccc cttggcattg atcctatttg gaacttggcc acaaatcgcc tcacttttct aaactctttc aaaatgaaaa tgtccgtgat tttaggaatc attcatatga cttttggagt cattctggga atatttaacc acttgcactt caggaagaag ttcaacattt acctggtttc catcccggaa cttctcttca tgctctgtat ctttggatac cttatattta tgattttcta caagtggctg gttttttcag cagaaacctc cagagttgct cccagcattc tgattgaatt tattaacatg tttttattcc cagccagtaa aacaagtggc ctttacacag ggcaggagta tgtccagaga gtgctgctgg ttgtcacagc attgtctgtc cctgtcctct tcttgggaaa gccactgttt ttgttgtggc ttcacaatgg gcgtagttgc ttcggggtga accggagtgg ctacacactt ataaggaaag atagtgagga agaagtttca ttgctgggaa gccaagatat agaagaggga aatcaccagg tggaagatgg atgtagagaa atggcgtgtg aagagtttaa ttttggagaa atattaatga cccaagtaat ccattccatc gagtactgtc tgggatgcat ctccaacacc gcctcctacc tgaggctctg ggcgcttagc ctggctcacg cacagttgtc tgatgtcctg tgggccatgc tgatgcgcgt gggcctccgc gttgacacca cctatggcgt cttgctactg ctcccggtta tcgcgctctt tgcagttttg accattttca tccttctgat catggaaggg ctttctgcgt ttcttcacgc catacgcctc cactgggtag aatttcagaa caaattctac gttggtgcag gcaccaaatt tgttcctttc tcattcagtc tactttcatc aaagttcaat aacgacgaca gtgtggcatg Protein function: Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). [The UniProt Consortium]