ARRDC3 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1245 Sequence: atggtgctgg gaaaggtgaa gagtttgaca ataagctttg actgtcttaa tgacagcaat gtccctgtgt attctagtgg ggataccgtc tcaggaaggg taaatttaga agttactggg gaaatcagag taaaatctct taaaattcat gcaagaggac atgcgaaagt acgctggact gaatctagaa acgccggctc caatactgcc tatacacaga attacactga agaagtagag tatttcaacc ataaagacat cttaattggg cacgaaagag atgatgataa ttccgaagaa ggcttccaca ctattcattc aggaaggcat gaatatgcat tcagcttcga gcttccacag acaccactcg ctacctcatt cgaaggccga catggcagtg tgcgctattg ggtgaaagcc gaattgcaca ggccttggct actaccagta aaattaaaga aggaatttac agtctttgag catatagata tcaacactcc ttcattactg tcaccccaag caggcacaaa agaaaagaca ctctgttgct ggttctgtac ctcaggccca atatccttaa gtgccaaaat tgaaaggaag ggctataccc caggtgaatc aattcagata tttgctgaga ttgagaactg ctcttcccga atggtggtgc caaaggcagc catttaccaa acacaggcct tctatgccaa agggaaaatg aaggaagtaa aacagcttgt ggctaacttg cgtggggaat ccttatcatc tggaaagaca gagacgtgga atggcaagtt gctgaaaatt ccaccagttt ctccctctat cctcgactgt agtataatcc gcgtggaata ttcactaatg gtatatgtgg atattcctgg agctatggat ttatttctta atttgccact tgtcatcggt accattcctc tacatccatt tggtagcaga acctcaagtg taagcagtca gtgtagcatg aatatgaact ggctcagttt atcacttcct gaaagacctg aagcaccacc cagctatgca gaagtggtaa cagaggaaca aaggcggaac aatcttgcac cagtgagtgc ttgtgatgac tttgagagag cccttcaagg accactgttt gcatatatcc aggagtttcg attcttgcct ccacctcttt attcagagat tgatccaaat cctgatcagt cagcagatga tagaccatcc tgcccctctc Protein function: Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein- coupled receptors (PubMed:20559325, PubMed:21982743, PubMed:23208550). Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation (PubMed:20559325, PubMed:23208550). May recruit NEDD4 to ADRB2 (PubMed:20559325). Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes (PubMed:23208550). [The UniProt Consortium]