ARRDC1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1302 Sequence: atggggcgag tgcagctctt cgagatcagc ctgagccacg gccgcgtcgt ctacagcccc ggggagccgt tggctgggac cgtgcgcgtg cgcctggggg caccgctgcc gttccgagcc atccgggtga cctgcatagg ttcctgcggg gtctccaaca aggctaatga cacagcgtgg gtagtggagg agggttactt caacagttcc ctgtcgctgg cagacaaggg gagcctgccc gctggagagc acagcttccc cttccagttc ctgcttcctg ccactgcacc cacgtccttt gagggtcctt tcgggaagat cgtgcaccag gtgagggccg ccatccacac gccacggttt tccaaggatc acaagtgcag cctcgtgttc tatatcttga gccccttgaa cctgaacagc atcccagaca ttgagcaacc caacgtggcc tctgccacca agaagttctc ctacaagctg gtgaagacgg gcagcgtggt cctcacagcc agcactgatc tccgcggcta tgtggtgggg caggcactgc agctgcatgc cgacgttgag aaccagtcag gcaaggacac cagccctgtg gtggccagtc tgctgcagaa agtgtcctat aaggccaagc gctggatcca cgacgtacgg accattgcgg aggtggaggg tgcgggcgtc aaggcctggc ggcgggcgca gtggcacgag cagatcctgg tgcctgcctt gccccagtcg gccctgccgg gctgcagcct catccacatc gactactact tacaggtctc tctgaaggcg ccggaagcta ctgtgaccct cccggtcttc attggcaata ttgctgtgaa ccatgcccca gtgagccccc ggccaggcct ggggctgcct cctggggccc cacccctggt ggtgccttcc gcaccacccc aggaggaggc tgaggctgag gctgcggctg gcggccccca cttcttggac cccgtcttcc tctccaccaa gagccattcg cagcggcagc ccctgctggc caccttgagt tctgtgcctg gtgcgccgga gccctgccct caggatggca gccctgcctc acacccgctg caccctccct tgtgcatttc aacaggtgcc actgtcccct actttgcaga gggctccggg gggccagtgc ccactaccag caccttgatt cttcctccag agtacagttc ttggggctac ccctatgagg ccccaccgtc ttatgagcag agctgcggcg gcgtggaacc cagcctgacc cctgagagct Protein function: Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed:23886940, PubMed:27462458). Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles (PubMed:27462458). More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles (PubMed:22315426). By participating in the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway (PubMed:23886940). [The UniProt Consortium]