ARL6IP1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 612 Sequence: atggcggagg gagataatcg cagcaccaac ctgctggctg cagagactgc aagtctggaa gaacagctgc aaggatgggg agaagtgatg ctgatggctg ataaagtcct ccgatgggaa agagcctggt ttccacctgc catcatgggt gtggtttctt tggtgtttct gattatctac tatctagatc catctgttct gtccggcgtt tcctgttttg ttatgttttt gtgcttggct gactaccttg ttcccattct agcgcctaga atttttggct ccaataaatg gaccactgaa caacagcaaa gattccatga aatttgcagc aatctagtaa aaactcgacg cagagctgtg ggttggtgga aacgcctctt cacactaaag gaagaaaaac ctaagatgta cttcatgacc atgatcgttt cccttgctgc ggttgcttgg gtgggacaac aagtccacaa cctgcttctc acctacctga tagtgacttc cttactattg cttcctggac taaaccaaca tggaatcatt ttgaagtaca ttggaatggc caagagggag ataaacaaac ttctcaaaca aaaagaaaag aaaaacgaat Protein function: Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity- dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport. Plays a role in the formation and stabilization of endoplasmic reticulum tubules (PubMed:24262037). Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates and downstream markers of apoptosis but not CASP9 itself (PubMed:12754298). May be involved in protein transport, membrane trafficking, or cell signaling during hematopoietic maturation (PubMed:10995579). [The UniProt Consortium]